Biology:Diadenosine hexaphosphate hydrolase (ATP-forming)
From HandWiki
| Diadenosine hexaphosphate hydrolase (ATP-forming) | |||||||||
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| Identifiers | |||||||||
| EC number | 3.6.1.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Diadenosine hexaphosphate hydrolase (ATP-forming) (EC 3.6.1.61, Ndx1) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming).[1] This enzyme catalyses the following chemical reaction
- (1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 2 ATP
- (2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] ATP + ADP
- (3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] ATP + AMP
The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+).
References
- ↑ "The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity". The Journal of Biological Chemistry 279 (21): 21732–9. May 2004. doi:10.1074/jbc.m312018200. PMID 15024014.
External links
- Diadenosine+hexaphosphate+hydrolase+(ATP-forming) at the US National Library of Medicine Medical Subject Headings (MeSH)
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