Biology:Microsomal glutathione S-transferase 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.[1]
Function
The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform.[1]
References
Further reading
- "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily.". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. 2000. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
- "What role do glutathione S-transferases play in the cellular response to ionizing radiation?". Int. J. Radiat. Oncol. Biol. Phys. 22 (4): 759–63. 1992. doi:10.1016/0360-3016(92)90519-N. PMID 1544849.
- "The gene for the microsomal glutathione S-transferase is on human chromosome 12.". Genomics 6 (2): 379–82. 1990. doi:10.1016/0888-7543(90)90580-N. PMID 2307478.
- "Gene expression of rat and human microsomal glutathione S-transferases.". J. Biol. Chem. 263 (17): 8430–6. 1988. doi:10.1016/S0021-9258(18)68495-9. PMID 3372534.
- "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- "Protein-protein interaction affinity chromatography of leukotriene C4 synthase.". Protein Expr. Purif. 6 (3): 352–6. 1995. doi:10.1006/prep.1995.1046. PMID 7663172.
- "Structural organization of the human microsomal glutathione S-transferase gene (GST12).". Genomics 36 (1): 100–3. 1997. doi:10.1006/geno.1996.0429. PMID 8812420.
- "Distribution of microsomal glutathione transferase 1 in mammalian tissues. A predominant alternate first exon in human tissues.". Eur. J. Biochem. 260 (2): 409–13. 1999. doi:10.1046/j.1432-1327.1999.00165.x. PMID 10095775.
- "Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene.". Biochim. Biophys. Acta 1446 (3): 389–96. 1999. doi:10.1016/S0167-4781(99)00112-8. PMID 10524215.
- "Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress.". J. Biol. Chem. 275 (17): 13000–6. 2000. doi:10.1074/jbc.275.17.13000. PMID 10777602.
- "Colocalization of leukotriene C synthase and microsomal glutathione S-transferase elucidated by indirect immunofluorescence analysis.". FEBS Lett. 480 (2–3): 239–43. 2000. doi:10.1016/S0014-5793(00)01885-8. PMID 11034337.
- "Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene". J. Hum. Genet. 46 (10): 590–4. 2001. doi:10.1007/s100380170026. PMID 11587073.
- "Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk". Cancer Lett. 187 (1–2): 95–101. 2003. doi:10.1016/S0304-3835(02)00406-8. PMID 12359356.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3". Biochim. Biophys. Acta 1627 (2–3): 79–84. 2003. doi:10.1016/S0167-4781(03)00077-0. PMID 12818425.
- "Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry". J. Biol. Chem. 279 (14): 13311–6. 2004. doi:10.1074/jbc.M310958200. PMID 14726533.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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