Biology:Mitochondrial ribosomal death-associated protein 3
From HandWiki
| DAP3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DAP3 | ||||||||
| Pfam | PF10236 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR019368 | ||||||||
| |||||||||
In molecular biology, the mitochondrial ribosomal death-associated protein 3 family of proteins is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis.[1] DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix[2] and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).
References
- ↑ "Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death". EMBO J. 18 (2): 353–62. January 1999. doi:10.1093/emboj/18.2.353. PMID 9889192.
- ↑ "The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins". J. Cell Sci. 113 (20): 3603–12. October 2000. PMID 11017876.
 |
