Chemistry:Potassium permanganate (medical use)

From HandWiki
Jump to: navigation, search

Potassium permanganate is used as a medication for a number of skin conditions.[1] This includes fungal infections of the foot, impetigo, pemphigus, superficial wounds, dermatitis, and tropical ulcers.[2][1] For tropical ulcers it is used together with procaine benzylpenicillin.[1] Typically it is used in skin conditions that produce a lot of liquid.[2] It can be applied as a soaked dressing or a bath.[1]

Side effects may include irritation of the skin and discoloration of clothing.[1] If it is taken by mouth, toxicity and death may occur.[3] Potassium permanganate is an oxidizing agent.[4] The British National Formulary recommends that each 100 mg be dissolved in a liter of water before use.[2]

Potassium permanganate was first made in the 1600s and came into common medical use at least as early as the 1800s.[5] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[6] The wholesale cost in the developing world is about 0.01 USD per g.[7] In the United Kingdom this amount costs the NHS about £1.33.[2]

Medical uses

Uses include for fungal infections of the foot, impetigo, pemphigus, superficial wounds, dermatitis (eczema), and tropical ulcers.[2][1] Typically it is used in skin conditions that produce a lot of liquid.[2] For tropical ulcers it is used together with procaine benzylpenicillin for two to four weeks.[1][8]

It can be used in children and adults.[8] It can be applied as a soaked dressing or a bath.[1] Petroleum jelly may be used on the nails before soaking to prevent their discoloration.[9] The U.S. Food and Drug Administration does not recommend its use in either the crystal or tablet form.[10]

Side effects

Topical

Side effects may include irritation of the skin and discoloration of clothing.[1] A harsh burn on a child from an undissolved tablet has been reported.[11] For treating eczema, it is recommended using for a few days at a time due to the possibility of it irritating the skin.[11] Higher concentration solutions can result in chemical burns.[12] Therefore, the British National Formulary recommends 100 mg be dissolved in a liter of water before use to form a 1:10,000 (0.01%) solution.[2][11] Wrapping the dressings soaked with potassium permanganate is not recommended.[8]

By mouth

If taken by mouth it is deemed to be very toxic.[13] Side effects may include nausea, vomiting, and shortness of breath may occur.[14] If a sufficiently large amount (about 10 grams) is eaten death may occur.[3][14]

Concentrated solutions when drunk have resulted in adult respiratory distress syndrome or swelling of the airway.[15] Recommended measures for those who have ingested potassium permanganate include gastroscopy.[15] Activated charcoal or medications to cause vomiting are not recommended.[15] While medications like ranitidine and N-acetylcysteine may be used in toxicity, evidence for this use is poor.[15]

Mechanism of action

Potassium permanganate functions as an oxidising agent.[16] Through this mechanism it results in disinfection, astringent effects, and decreased smell.[16]

History

Potassium permanganate was first made in the 1600s and came into common medical use at least as early as the 1800s.[5] During World War I Canadian soldiers were given potassium permanganate in an effort to prevent sexually transmitted infections.[17] Some have attempted to bring about an abortion by putting it in the vagina, though this is not effective.[18][19][20] Other historical uses have included as an effort to wash out the stomach in those with strychnine or picrotoxin poisoning.[21]

Society and culture

It is available under a number of brand names including Permasol, Koi Med Tricho-Ex, and Kalii permanganas RFF.[22] It is occasionally called "Condy's crystals".[16]

Other animals

Potassium permanganate may be used to prevent the spread of glanders among horses.[23]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 WHO Model Formulary 2008. World Health Organization. 2009. pp. 295, 300. ISBN 9789241547659. 
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 British Medical Association; Royal Pharmaceutical Society (2015). British national formulary (69 ed.). p. 840. ISBN 9780857111562. 
  3. 3.0 3.1 Shai, Avi; Maibach, Howard I. (2005) (in en). Wound Healing and Ulcers of the Skin: Diagnosis and Therapy - The Practical Approach. Springer Science & Business Media. p. 265. ISBN 9783540267614. https://books.google.ca/books?id=tYzut85bKlcC&pg=PA265. 
  4. Kasture, A. V.; Wadodkar, S. G.; Gokhale, S. B. (2008) (in en). Practical Pharmaceutical Chemistry - I. Nirali Prakashan. ISBN 9788185790442. https://books.google.ca/books?id=P3nyl66NcF4C&pg=PA53. 
  5. 5.0 5.1 Stout, Meg (2013) (in en). The Complete Idiot's Guide to Aquaponic Gardening. Penguin. p. Chapter 16. ISBN 9781615643332. https://books.google.ca/books?id=BIfEfqS8iKcC&pg=RA1-PT234. 
  6. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  7. "Potassium Permanganate". http://mshpriceguide.org/en/single-drug-information/?DMFId=644&searchYear=2014. Retrieved 8 December 2016. 
  8. 8.0 8.1 8.2 "WHO Model Prescribing Information: Drugs Used in Skin Diseases: Antiseptic agents: Potassium permanganate". http://apps.who.int/medicinedocs/en/d/Jh2918e/25.2.html. Retrieved 12 October 2017. 
  9. Burge, Susan; Wallis, Dinny (2011) (in en). Oxford Handbook of Medical Dermatology. OUP Oxford. p. 592. ISBN 9780199558322. https://books.google.ca/books?id=CDxsjyTSnawC&pg=PA592. 
  10. "CFR - Code of Federal Regulations Title 21". https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=250.108. Retrieved 11 October 2017. 
  11. 11.0 11.1 11.2 "Should potassium permanganate be used in wound care?" (in en). 5 August 2003. https://www.nursingtimes.net/clinical-archive/wound-care/should-potassium-permanganate-be-used-in-wound-care/205220.article. Retrieved 12 October 2017. 
  12. Olson, Kent R. (2011) (in en). Poisoning and Drug Overdose, Sixth Edition. McGraw Hill Professional. p. 121. ISBN 9780071716765. https://books.google.ca/books?id=ju7diy73Z2wC&q. 
  13. Schachner, Lawrence A.; Hansen, Ronald C. (2011) (in en). Pediatric Dermatology E-Book. Elsevier Health Sciences. p. 131. ISBN 0723436657. https://books.google.ca/books?id=tAlGLYplkacC&pg=PA131. 
  14. 14.0 14.1 Patnaik, Pradyot (2007) (in en). A Comprehensive Guide to the Hazardous Properties of Chemical Substances. John Wiley & Sons. p. 710. ISBN 9780471714583. https://books.google.ca/books?id=-CRRJBVv5d0C&pg=PA710. 
  15. 15.0 15.1 15.2 15.3 Dart, Richard C. (2004) (in en). Medical Toxicology. Lippincott Williams & Wilkins. pp. 904–905. ISBN 9780781728454. https://books.google.ca/books?id=BfdighlyGiwC&pg=PA904. 
  16. 16.0 16.1 16.2 "Potassium permanganate | DermNet New Zealand" (in en). https://www.dermnetnz.org/topics/potassium-permanganate/. Retrieved 11 October 2017. 
  17. González-Crussi, F. (2008) (in en). A Short History of Medicine. Random House Publishing Group. p. 111. ISBN 9781588368218. https://books.google.ca/books?id=bKpBZi8uG8IC&pg=PA111. 
  18. Solinger, Rickie (2005) (in en). Pregnancy and Power: A Short History of Reproductive Politics in America. NYU Press. p. 120. ISBN 9780814741191. https://books.google.ca/books?id=Xe6gBwAAQBAJ&pg=PA120. 
  19. (in en) Code of Federal Regulations: Record 2: 2007-. U.S. General Services Administration, National Archives and Records Service, Office of the Federal Register. 2008. p. 178. https://books.google.ca/books?id=SbVRAQAAMAAJ&q. 
  20. "CFR - Code of Federal Regulations Title 21". https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=250.108. Retrieved 11 October 2017. 
  21. "Potassium permanganate definition | Drugs.com". https://www.drugs.com/dict/potassium-permanganate.html. Retrieved 11 October 2017. 
  22. "Potassium Permanganate - Drugs.com". https://www.drugs.com/international/potassium-permanganate.html. Retrieved 11 October 2017. 
  23. Scott, Danny W.; Miller, William H. (2010) (in en). Equine Dermatology - E-Book. Elsevier Health Sciences. p. 168. ISBN 1437709214. https://books.google.ca/books?id=f0-v1vOq3x4C&pg=PA168. 


Grammarly Check DataMelt statistical framewwork for data scientists RTextDoc LaTeX editor HandWiki ads