# Medicine:Armitage–Doll multistage model of carcinogenesis

The **Armitage–Doll model** is a statistical model of carcinogenesis, proposed in 1954 by Peter Armitage and Richard Doll, which suggested that a sequence of multiple distinct genetic events preceded the onset of cancer. The original paper has recently been reprinted with a set of commentary articles.

## References[edit]

- Armitage, P. and Doll, R. (1954) "The Age Distribution of Cancer and a Multi-Stage Theory Of Carcinogenesis",
*British Journ. of Cancer*, 8 (1), 1-12. Reprinted (2004): reprint,*British Journal of Cancer*, 91, 1983–1989. doi:10.1038/sj.bjc.6602297 - P Armitage and R Doll (2004) "The age distribution of cancer and a multi-stage theory of carcinogenosis",
*Int. J. Epidemiol*33(6): 1174-1179 doi:10.1093/ije/dyh216 - Steven A Frank (2004) "Commentary: Mathematical models of cancer progression and epidemiology in the age of high throughput genomics",
*Int. J. Epidemiol.*33(6): 1179-1181 doi:10.1093/ije/dyh222 - Suresh H Moolgavkar (2004) "Commentary: Fifty years of the multistage model: remarks on a landmark paper",
*Int. J. Epidemiol.*33(6): 1182-1183 doi:10.1093/ije/dyh288 - Richard Doll (2004) "Commentary: The age distribution of cancer and a multistage theory of carcinogenesis",
*Int. J. Epidemiol.*33(6): 1183-1184 doi:10.1093/ije/dyh359

*https://en.wikipedia.org/wiki/Armitage–Doll multistage model of carcinogenesis was the original source. Read more*.