Medicine:Armitage–Doll multistage model of carcinogenesis

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The Armitage–Doll model is a statistical model of carcinogenesis, proposed in 1954 by Peter Armitage and Richard Doll, which suggested that a sequence of multiple distinct genetic events preceded the onset of cancer. The original paper has recently been reprinted with a set of commentary articles.

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https://en.wikipedia.org/wiki/Armitage–Doll multistage model of carcinogenesis was the original source. Read more.