View source for Biology:Monocarboxylate transporter 3

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Monocarboxylate transporter 3''' (MCT3) also known as '''solute carrier family 16 member 8''' is a [[Biology:Protein|protein]] that in humans is encoded by the ''SLC16A8'' [[Biology:Gene|gene]].<ref>{{cite journal | vauthors = Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS | title = Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle | journal = Cell | volume = 76 | issue = 5 | pages = 865–73 | date = Mar 1994 | pmid = 8124722 | doi = 10.1016/0092-8674(94)90361-1 | s2cid = 22137883 }}</ref> MCT is a proton-coupled [[Biology:Monocarboxylate transporter|monocarboxylate transporter]]. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Expression of SLC16A8 is confined to the [[Medicine:Retinal pigment epithelium|retinal pigment epithelium]] and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

== See also ==
* [[Biology:Monocarboxylate transporter|Monocarboxylate transporter]]

== References ==
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== Further reading ==
{{refbegin}}
* {{cite journal | vauthors = Yoon H, Donoso LA, Philp NJ | title = Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2 | journal = Genomics | volume = 60 | issue = 3 | pages = 366–70 | year = 1999 | pmid = 10493836 | doi = 10.1006/geno.1999.5926 }}
* {{cite journal | vauthors = Philp NJ, Wang D, Yoon H, Hjelmeland LM | title = Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells | journal = Invest. Ophthalmol. Vis. Sci. | volume = 44 | issue = 4 | pages = 1716–21 | year = 2003 | pmid = 12657613 | doi = 10.1167/iovs.02-0287| doi-access =  }}
* {{cite journal | vauthors = Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP | title = Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70) | journal = J. Biol. Chem. | volume = 280 | issue = 29 | pages = 27213–21 | year = 2005 | pmid = 15917240 | doi = 10.1074/jbc.M411950200 | doi-access = free }}
* {{cite journal | vauthors = Cori CF | title = The glucose-lactic acid cycle and gluconeogenesis | journal = Curr. Top. Cell. Regul. | series = Current Topics in Cellular Regulation | volume = 18 | pages = 377–87 | year = 1981 | doi = 10.1016/B978-0-12-152818-8.50028-1 | pmid = 7273846 | isbn = 9780121528188 }}
* {{cite journal | vauthors = Halestrap AP, Meredith D | title = The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond | journal = Pflügers Arch. | volume = 447 | issue = 5 | pages = 619–28 | year = 2004 | pmid = 12739169 | doi = 10.1007/s00424-003-1067-2 | s2cid = 15498611 }}
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{{Membrane transport proteins|bg|bg1}}

[[Category:Solute carrier family]]



{{Sourceattribution|Monocarboxylate transporter 3}}