View source for Chemistry:Binding coefficient

In [[Chemistry:Medicinal chemistry|medicinal chemistry]] and [[Biology:Pharmacology|pharmacology]], a '''binding coefficient''' is a quantity representing the extent to which a [[Chemistry:Chemical compound|chemical compound]] will bind to a [[Biology:Macromolecule|macromolecule]].<ref>Schurr JM, Rangel DP, Aragon SR. (2005) [http://www.biophysj.org/cgi/content/full/89/4/2258 "A Contribution to the Theory of Preferential Interaction Coefficients."] {{webarchive |url=https://web.archive.org/web/20071011150218/http://www.biophysj.org/cgi/content/full/89/4/2258 |date=October 11, 2007 }} ''Biophysical Journal.'' '''89''':2258-2276.</ref><ref>Shulgin IL, Ruckenstein E (2006) [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1367075 "A Protein Molecule in a Mixed Solvent: The Preferential Binding Parameter via the Kirkwood-Buff theory."] ''Biophysical Journal.'' '''90''':704–707.</ref> The preferential binding coefficient can be derived from the Kirkwood-Buff solution theory of solutions. Preferential binding is defined as a thermodynamic expression that describes the binding of the cosolvent over the solvent. This is in a system that is open to both the solvent and cosolvent. <ref> Pierce V, Kang M, Weerasinghe S, Smith PE. (2008) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566781/ "Recent Applications of Kirkwood-Buff Theory to Biological Systems."] ''Cell Biochem Biophys.'' '''50'''(1):1-22.</ref> Consequently, preferential interaction coefficients are measures of interactions that involve “solutes that participate in a reaction in solution.” <ref>Thomas Record Jr. M, Anderson CF. (1995) [http://ac.els-cdn.com/S0006349595802547/1-s2.0-S0006349595802547-main.pdf?_tid=49b2b2c6-4cb8-11e3-8196-00000aab0f27&acdnat=1384384194_226f73535656c79106cae9511103cd8e "Interpretation of Preferential Interaction Coefficients of Nonelectrolytes and of Electrolyte Ions in Terms of a Two-Domain Model."] ''Biophysical Journal.'' '''68''':786-794.</ref>
== See also ==
* [[Chemistry:Binding constant|Binding constant]]
* [[Physics:Partition coefficient|Partition coefficient]]
* Binding affinity

== References ==
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{{Medicinal chemistry}}

[[Category:Medicinal chemistry]]



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