View source for Medicine:Bolivian hemorrhagic fever

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| parent = Mammarenavirus
| species = Machupo mammarenavirus
| synonyms = ''Machupo virus''
| synonyms_ref = <ref>{{cite web |title=ICTV Taxonomy history: ''Machupo mammarenavirus'' |url=https://ictv.global/taxonomy/taxondetails?taxnode_id=20182587 |website=International Committee on Taxonomy of Viruses (ICTV) |access-date=28 January 2019 |language=en }}</ref>
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{{Infobox medical condition (new)
| name            = Bolivian hemorrhagic fever
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| field           = [[Medicine:Infectious disease (medical specialty)|Infectious disease]]
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'''Bolivian hemorrhagic fever''' ('''BHF'''), also known as '''black typhus''' or '''Ordog Fever''', is a hemorrhagic fever and [[Biology:Zoonosis|zoonotic]] [[Medicine:Infectious disease|infectious disease]] originating in Bolivia after infection by '''''Machupo mammarenavirus'''''.<ref name="PHAC">Public Health Agency of Canada: ''Machupo Virus Pathogen Safety Data Sheet'', http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/machupo-eng.php, Date Modified: 2011-02-18.</ref>

BHF was first identified in 1963 as an ambisense [[Biology:RNA virus|RNA virus]] of the ''[[Biology:Arenaviridae|Arenaviridae]]'' family,<ref name="urlMachupo">{{Cite web|url=http://www.stanford.edu/group/virus/arena/2005/MachupoVirus.htm |title=Machupo |access-date=2009-01-22}}</ref><ref name="pmid4378149">{{Cite journal|vauthors=Webb PA, Johnson KM, Mackenzie RB, Kuns ML |title=Some characteristics of Machupo virus, causative agent of Bolivian hemorrhagic fever |journal=Am. J. Trop. Med. Hyg. |volume=16 |issue=4 |pages=531–8 |date=July 1967 |pmid=4378149 |doi=10.4269/ajtmh.1967.16.531 }}</ref> by a research group led by Karl Johnson. The mortality rate is estimated at 5 to 30 percent. Due to its pathogenicity, Machupo virus requires Biosafety Level Four conditions, the highest level.<ref name="CFSPH">Center for Food Security & Public Health and Institute for International Cooperation in Animal Biologics, Iowa State University: ''Viral Hemorrhagic Fevers Caused by Arenaviruses'', http://www.cfsph.iastate.edu/Factsheets/pdfs/viral_hemorrhagic_fever_arenavirus.pdf, last updated: February 23, 2010.</ref>

During the period between February and March 2007, some 20 suspected BHF cases (3 fatal) were reported to the Servicio Departamental de Salud (SEDES) in Beni Department, Bolivia. In February 2008, at least 200 suspected new cases (12 fatal) were reported to SEDES.<ref name="Carmago et al">Aguilar PV, Carmago W, Vargas J, Guevara C, Roca Y, Felices V, et al. Reemergence of Bolivian hemorrhagic fever, 2007–2008 [letter]. Emerg Infect Dis [serial on the Internet] 2009 Sep. Available from http://wwwnc.cdc.gov/eid/article/15/9/09-0017.htm. Accessed 2 Dec 2011.</ref> In November 2011, a second case was confirmed near the departmental capital of Trinidad, and a serosurvey was conducted to determine the extent of Machupo virus infections in the department. A SEDES expert involved in the survey expressed his concerns about the expansion of the virus to other provinces outside the endemic regions of Mamoré and Iténez provinces.<ref name="LTC">"Caso confirmado de fiebre hemorrágica alerta a autoridades benianas," ''Los Tiempos.com'', {{cite web |url=http://www.lostiempos.com/diario/actualidad/nacional/20111116/caso-confirmado-de-fiebre-hemorragica-alerta-a-autoridades_149655_310330.html |title=Caso confirmado de fiebre hemorrágica alerta a autoridades benianas |access-date=2012-11-29 |url-status=dead |archive-url=https://web.archive.org/web/20120315191323/http://www.lostiempos.com/diario/actualidad/nacional/20111116/caso-confirmado-de-fiebre-hemorragica-alerta-a-autoridades_149655_310330.html |archive-date=2012-03-15 }}, 16/11/2011.</ref><ref name="LTC2">"SEDES movilizado para controlar brote de fiebre hemorrágica en Beni; También se Capacita a Los Comunarios y Estudiantes," ''Lost Tiempos.com'', {{cite web |url=http://www.lostiempos.com/diario/actualidad/nacional/20111130/sedes-movilizado-para-controlar-brote-de-fiebre-hemorragica-en_151529_314539.html |title=SEDES movilizado para controlar brote de fiebre hemorrágica en Beni |access-date=2012-11-29 |url-status=dead |archive-url=https://web.archive.org/web/20111201231957/http://www.lostiempos.com/diario/actualidad/nacional/20111130/sedes-movilizado-para-controlar-brote-de-fiebre-hemorragica-en_151529_314539.html |archive-date=2011-12-01 }}, 30/11/2011.</ref>

==Epidemiology==

=== History ===
The disease was first encountered in 1962, in the Bolivian village of San Joaquín, hence the name "Bolivian" Hemorrhagic Fever. When initial investigations failed to find an arthropod carrier, other sources were sought before finally determining that the disease was carried by infected mice. Although mosquitoes were not the cause as originally suspected, the extermination of mosquitoes using DDT to prevent malaria proved to be indirectly responsible for the outbreak in that the accumulation of DDT in various animals along the food chain led to a shortage of cats in the village; subsequently, a mouse plague erupted in the village, leading to an epidemic.<ref>Medical Microbiology 2nd edition; Mims et al. Mosby publishing 1998, p 371</ref>

=== Vectors ===
The [[Biology:Vector (epidemiology)|vector]] is the  [[Biology:Large vesper mouse|large vesper mouse]] (''Calomys callosus''), a [[Biology:Rodent|rodent]] indigenous to northern Bolivia. Infected animals are asymptomatic and shed the virus in excreta, thereby infecting humans. Evidence of person-to-person transmission of BHF exists but is believed to be rare.<ref name="Kilgore1995">Kilgore, et al., (1995).</ref>

===Symptoms===
The [[Medicine:Infection|infection]] has a slow onset with [[Medicine:Fever|fever]], malaise, [[Medicine:Headache|headache]] and [[Medicine:Myalgia|myalgia]], very similar to [[Medicine:Malaria|Malaria]] symptoms. Petechiae (blood spots) on the upper body and bleeding from the [[Medicine:Human nose|nose]] and gums are observed when the disease progresses to the hemorrhagic phase, usually within seven days of onset.<ref name="Kilgore1995" />  Severe hemorrhagic or neurologic symptoms are observed in about one third of patients. Neurologic symptoms involve tremors, delirium, and convulsions. The mortality rate is about 25%.<ref name=Patterson2014>{{cite journal |vauthors=Patterson M, Grant A, Paessler S |title=Epidemiology and pathogenesis of Bolivian hemorrhagic fever |journal=Current Opinion in Virology |volume=5 |pages=82–90 |year=2014 |pmid=24636947 |pmc=4028408 |doi=10.1016/j.coviro.2014.02.007 }}</ref>

===Prevention===
Measures to reduce contact between the vesper mouse and humans may have contributed to limiting the number of outbreaks, with no cases identified between 1973 and 1994. Although there are no cures or vaccine for the disease, a vaccine developed for the genetically related Junín virus which causes [[Medicine:Argentine hemorrhagic fever|Argentine hemorrhagic fever]] has shown evidence of cross-reactivity to Machupo virus, and may therefore be an effective prophylactic measure for people at high risk of infection. Post infection (and providing that the person survives the infection), those that have contracted BHF are usually immune to further infection of the disease.<ref name="Kilgore1995" />

==Weaponization==
Bolivian hemorrhagic fever was one of three hemorrhagic fevers and one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological weapons program in 1969.<ref name=jmcenter>"[http://webarchive.loc.gov/all/20011002153149/http://www.cns.miis.edu/research/cbw/possess.htm Chemical and Biological Weapons: Possession and Programs Past and Present]", ''James Martin Center for Nonproliferation Studies'', [[Organization:Middlebury College|Middlebury College]], April 9, 2002, accessed November 14, 2008.</ref> Albert Nickel, a 53-year old animal caretaker at Fort Detrick, died in 1964 from the disease after being bitten by an infected mouse. Nickel Place, on Fort Detrick, is named in his honor. It was also under research by the Soviet Union, under the [[Social:Biopreparat|Biopreparat]] bureau.<ref>Alibek, Ken and Steven Handelman (1999), ''Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World - Told from Inside by the Man Who Ran It'', Random House, {{ISBN|0-385-33496-6}}.</ref>

==Vaccine research==
Investigational vaccines exist for Argentine hemorrhagic fever and RVF; however, neither is approved by FDA or commonly available in the United States.<ref>{{cite web|url=https://wwwnc.cdc.gov/travel/yellowbook/2020/travel-related-infectious-diseases/viral-hemorrhagic-fevers|title=Travelers' Health: Viral Hemorrhagic Fevers|vauthors=Shoemaker T, Choi M|website=CDC|access-date=15 September 2020}}</ref>

The structure of the attachment glycoprotein has been determined by X-ray crystallography and this glycoprotein is likely to be an essential component of any successful vaccine.<ref>{{Cite journal|last1=Bowden|first1=Thomas A.|last2=Crispin|first2=Max|last3=Graham|first3=Stephen C.|last4=Harvey|first4=David J.|last5=Grimes|first5=Jonathan M.|last6=Jones|first6=E. Yvonne|last7=Stuart|first7=David I.|date=2009-08-15|title=Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein|journal=Journal of Virology|language=en|volume=83|issue=16|pages=8259–8265|doi=10.1128/JVI.00761-09|issn=0022-538X|pmc=2715760|pmid=19494008}}</ref>

==References==
{{Reflist}}

===Bibliography===
{{Refbegin}}
* {{cite journal|vauthors=Kilgore PE, Peters CJ, Mills JN |title=Prospects for the control of Bolivian hemorrhagic fever |journal=Emerging Infect. Dis. |volume=1 |issue=3 |pages=97–100 |year=1995 |pmid=8903174 |doi= 10.3201/eid0103.950308 |pmc=2626873|display-authors=0|ref=Kilgore1995}}
{{Refend}}
* Medical Microbiology 2nd Edition Mims et al. Mosby Publishing 1998 p 371

== External links ==
{{Medical resources
|  DiseasesDB     = 31899
|  ICD10          = {{ICD10|A|96|1|a|90}}
|  ICD9           = {{ICD9|078.7}}
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|  MeshID         = D006478
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{{Zoonotic viral diseases}}
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{{DEFAULTSORT:Bolivian Hemorrhagic Fever}}
[[Category:Rodent-carried diseases]]

{{Sourceattribution|Bolivian hemorrhagic fever}}