Chemistry:Chlorisondamine

Chlorisondamine
Clinical data
ATC code	None;
Identifiers
	IUPAC name Trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride;
CAS Number	7701-62-4 ;
PubChem CID	6243;
ChemSpider	6008 ;
UNII	JD3M24F66I;
ChEMBL	ChEMBL2104531 ;
Chemical and physical data
Formula	C14H20Cl6N2
Molar mass	429.03 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Cl-].[Cl-].Clc1c2c(c(Cl)c(Cl)c1Cl)C[N+](C2)(C)CC[N+](C)(C)C;
	InChI InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2 ; Key:IXWDUZLHWJKVPX-UHFFFAOYSA-N ;
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Short description: Chemical compound

Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids.^[1]^[2]^[3]

References

↑ "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research 2 (2): 207–12. 2003. doi:10.1021/pr025578h. PMID 12716135.
↑ "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry 16 (2): 133–8. February 2005. doi:10.1016/j.jasms.2004.10.002. PMID 15694763.
↑ "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry 76 (8): 2187–95. April 2004. doi:10.1021/ac035376k. PMID 15080727.

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Original source: https://en.wikipedia.org/wiki/Chlorisondamine. Read more

[pmid12716135-1] "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research 2 (2): 207–12. 2003. doi:10.1021/pr025578h. PMID 12716135.

[pmid15694763-2] "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry 16 (2): 133–8. February 2005. doi:10.1016/j.jasms.2004.10.002. PMID 15694763.

[pmid15080727-3] "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry 76 (8): 2187–95. April 2004. doi:10.1021/ac035376k. PMID 15080727.

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Clinical data

ATC code	None
Identifiers
IUPAC name Trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride
CAS Number	7701-62-4^Y
PubChem CID	6243
ChemSpider	6008^Y
UNII	JD3M24F66I
ChEMBL	ChEMBL2104531^N
Chemical and physical data
Formula	C₁₄H₂₀Cl₆N₂
Molar mass	429.03 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [Cl-].[Cl-].Clc1c2c(c(Cl)c(Cl)c1Cl)C[N+](C2)(C)CC[N+](C)(C)C
InChI InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2^Y Key:IXWDUZLHWJKVPX-UHFFFAOYSA-N^Y
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