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Short description: Chemical compound
3-Quinuclidinyl thiochromane-4-carboxylate |
Identifiers |
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1-azabicyclo[2.2.2]octan-3-yl 3,4-dihydro-2H-1-benzothiopyran-4-carboxylate
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PubChem CID | |
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Chemical and physical data |
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Formula | C17H21NO2S |
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Molar mass | 303.42 g·mol−1 |
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3D model (JSmol) | |
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O=C(OC1CN2CCC1CC2)C1CCSc2ccccc21
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InChI=1S/C17H21NO2S/c19-17(20-15-11-18-8-5-12(15)6-9-18)14-7-10-21-16-4-2-1-3-13(14)16/h1-4,12,14-15H,5-11H2 Key:WKRAGTKCJCJQIR-UHFFFAOYSA-N
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3-Quinuclidinyl thiochromane-4-carboxylate is a research compound which is one of the most potent muscarinic antagonists known. Tests in vitro showed it to have a binding affinity over 1000 times more potent than 3-quinuclidinyl benzilate.[1][2]
See also
References
- ↑ "Synthesis and structure-activity relationships of new muscarinic antagonists". Journal of Pharmaceutical Sciences 76 (10): 848–50. October 1987. doi:10.1002/jps.2600761020. PMID 3430351.
- ↑ "Dual Use Research of Concern: Derivatives of 3-Quinuclidinyl Benzilate". Military Medical Science Letters 84 (1): 2–41. 2015. doi:10.31482/mmsl.2015.001.
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mAChRs | Agonists | |
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Antagonists |
- 3-Quinuclidinyl benzilate
- 4-DAMP
- Aclidinium bromide (+formoterol)
- Abediterol
- AF-DX 250
- AF-DX 384
- Ambutonium bromide
- Anisodamine
- Anisodine
- Antihistamines (first-generation) (e.g., brompheniramine, buclizine, captodiame, chlorphenamine (chlorpheniramine), cinnarizine, clemastine, cyproheptadine, dimenhydrinate, [[Chemistry:Dimetdimetindene, Diphenhydramine|diphenhydramine]], doxylamine, meclizine, mepyramine (pyrilamine), mequitazine, perlapine, phenindamine, pheniramine, Phenyltoloxamine|Phenyltoloxamine]]]], promethazine, propiomazine, triprolidine)
- AQ-RA 741
- Atropine
- Atropine methonitrate
- Atypical antipsychotics (e.g., clozapine, Chemistry:Fluperlapine
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Precursors (and prodrugs) | |
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