Biology:ARFRP1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.[1][2]
Function
The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.[2]
Interactions
ARFRP1 has been shown to interact with PSCD1.[3]
References
- ↑ "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem 270 (51): 30657–63. Jan 1996. doi:10.1074/jbc.270.51.30657. PMID 8530503.
- ↑ 2.0 2.1 "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10139.
- ↑ "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. April 1999. doi:10.1074/jbc.274.14.9744. PMID 10092663.
Further reading
- "Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.". Mol. Membr. Biol. 23 (6): 475–85. 2007. doi:10.1080/09687860600840100. PMID 17127620.
- "Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking.". J. Cell Sci. 118 (Pt 17): 4039–48. 2005. doi:10.1242/jcs.02524. PMID 16129887.
- "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.". Nat. Cell Biol. 6 (5): 405–13. 2004. doi:10.1038/ncb1120. PMID 15077113.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.". J. Biol. Chem. 276 (35): 32756–62. 2001. doi:10.1074/jbc.M100929200. PMID 11438518.
- "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1230–5. 2000. doi:10.1073/pnas.97.3.1230. PMID 10655513. Bibcode: 2000PNAS...97.1230B.
- "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D.". J. Biol. Chem. 274 (14): 9744–51. 1999. doi:10.1074/jbc.274.14.9744. PMID 10092663.
External links
- ARFRP1 human gene location in the UCSC Genome Browser.
- ARFRP1 human gene details in the UCSC Genome Browser.
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