Biology:IRF2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.

Function

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.

See also

• IRF1
• Interferon regulatory factors

Interactions

IRF2 has been shown to interact with BRD7, EP300 and PCAF.

Further reading

• "The role of interferon regulatory factors in the interferon system and cell growth control". Biochimie 80 (8–9): 641–50. 1999. doi:10.1016/S0300-9084(99)80017-0. PMID 9865486. 
• "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie 80 (8–9): 651–8. 1999. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487. 
• "Sequence of a cDNA coding for human IRF-2". Nucleic Acids Res. 17 (20): 8372. 1989. doi:10.1093/nar/17.20.8372. PMID 2813069. 
• "Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system". Mol. Cell. Biol. 14 (2): 1500–9. 1994. doi:10.1128/MCB.14.2.1500. PMID 7507207. 
• "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf. 
• "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. 1995. doi:10.1074/jbc.270.22.13063. PMID 7768900. 
• "Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region". J. Biol. Chem. 269 (7): 5279–87. 1994. doi:10.1016/S0021-9258(17)37685-8. PMID 8106512. 
• "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2". Science 259 (5097): 971–4. 1993. doi:10.1126/science.8438157. PMID 8438157. Bibcode: 1993Sci...259..971H. 
• "Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells". J. Neuroimmunol. 63 (2): 157–62. 1996. doi:10.1016/0165-5728(95)00140-9. PMID 8550813. https://zenodo.org/record/1258359. 
• "Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo". J. Cell. Biochem. 66 (2): 175–83. 1997. doi:10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N. PMID 9213219. 
• "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. 1999. doi:10.1128/MCB.19.3.1810. PMID 10022868. 
• "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci. 40 (5): 976–82. 1999. PMID 10102295. 
• "Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays". Ann. Neurol. 46 (3): 425–8. 1999. doi:10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O. PMID 10482277. 
• "Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia". Leuk. Lymphoma 35 (5–6): 507–11. 2000. doi:10.1080/10428199909169615. PMID 10609788. 
• "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. 2000. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449. 
• "Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5". J. Viral Hepat. 8 (2): 103–10. 2001. doi:10.1046/j.1365-2893.2001.00273.x. PMID 11264730. 
• "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. 2001. doi:10.1074/jbc.M101707200. PMID 11304541. 

External links

• IRF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.