Biology:Neurogenin-3
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Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.[1]
Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine.[2] It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.[3]
Neurogenin 3 (NGN3) is expressed by 2-10% of acinar and duct cells in the histologically normal adult human pancreas. NGN3+ cells isolated from cultured exocrine tissue by coexpressed cell surface glycoprotein CD133 have a transcriptome consistent with exocrine dedifferentiation, a phenotype that resembles endocrine progenitor cells during development, and a capacity for endocrine differentiation in vitro.[4] Human[5] and rodent[6][7][8][9][10][11][12][13][14] exocrine cells have been reprogrammed into cells with an islet cell-like phenotype following direct expression of NGN3 or manipulation that leads to its expression.
Detail
Much more at Neurogenins#Neurogenin-3
References
- ↑ "Entrez Gene: neurogenin 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50674.
- ↑ "Mutant neurogenin-3 in congenital malabsorptive diarrhea". The New England Journal of Medicine 355 (3): 270–80. Jul 2006. doi:10.1056/NEJMoa054288. PMID 16855267.
- ↑ "neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas". Proceedings of the National Academy of Sciences of the United States of America 97 (4): 1607–11. Feb 2000. doi:10.1073/pnas.97.4.1607. PMID 10677506. Bibcode: 2000PNAS...97.1607G.
- ↑ "Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate". PLOS ONE 10 (8): e0133862. 2015. doi:10.1371/journal.pone.0133862. PMID 26288179. Bibcode: 2015PLoSO..1033862G.
- ↑ "Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming". PLOS ONE 7 (5): e37055. 2012. doi:10.1371/journal.pone.0037055. PMID 22606327. Bibcode: 2012PLoSO...737055S.
- ↑ "Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas". Cell 132 (2): 197–207. Jan 2008. doi:10.1016/j.cell.2007.12.015. PMID 18243096.
- ↑ "Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas". Cell Death & Disease 4 (3): e523. 7 March 2013. doi:10.1038/cddis.2013.52. PMID 23470530.
- ↑ "Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat". Molecular Therapy 20 (10): 1944–52. Oct 2012. doi:10.1038/mt.2012.112. PMID 22828498.
- ↑ "Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats". Journal of Cell Science 123 (Pt 16): 2792–802. Aug 2010. doi:10.1242/jcs.065268. PMID 20663919.
- ↑ "Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice". Nature Biotechnology 32 (1): 76–83. Jan 2014. doi:10.1038/nbt.2747. PMID 24240391.
- ↑ "Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway". Cell Death and Differentiation 13 (11): 1892–9. Nov 2006. doi:10.1038/sj.cdd.4401883. PMID 16514419.
- ↑ "Reprogramming of human pancreatic exocrine cells to β-like cells". Cell Death and Differentiation 22 (7): 1117–30. Jul 2015. doi:10.1038/cdd.2014.193. PMID 25476775.
- ↑ "In vivo reprogramming of adult pancreatic exocrine cells to beta-cells". Nature 455 (7213): 627–32. Oct 2008. doi:10.1038/nature07314. PMID 18754011. Bibcode: 2008Natur.455..627Z.
- ↑ "Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells". Cell Stem Cell 15 (2): 139–53. Aug 2014. doi:10.1016/j.stem.2014.06.019. PMID 25105579.
Further reading
- "Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells". Pancreas 38 (3): 259–66. Apr 2009. doi:10.1097/MPA.0b013e3181930818. PMID 19307926.
- "Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects". Diabetes 50 (3): 694–6. Mar 2001. doi:10.2337/diabetes.50.3.694. PMID 11246894.
- "Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study". Journal of Molecular Medicine 86 (3): 341–8. Mar 2008. doi:10.1007/s00109-007-0295-x. PMID 18210030.
- "Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population". Diabetologia 44 (1): 123–6. Jan 2001. doi:10.1007/s001250051589. PMID 11206403.
- "Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value". PLOS ONE 3 (5): e2031. 2008. doi:10.1371/journal.pone.0002031. PMID 18461161. Bibcode: 2008PLoSO...3.2031C.
- "Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes". Diabetes, Obesity & Metabolism 10 (10): 912–20. Sep 2008. doi:10.1111/j.1463-1326.2007.00830.x. PMID 18093211.
- "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes 55 (8): 2379–86. Aug 2006. doi:10.2337/db05-1203. PMID 16873704.
- "NEUROG3 variants and type 2 diabetes in Italians". Minerva Medica 97 (5): 373–8. Oct 2006. PMID 17146417.
- "Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes". Experimental and Clinical Endocrinology & Diabetes 116 (3): 178–83. Mar 2008. doi:10.1055/s-2007-992156. PMID 18072012.
- "Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells". Diabetologia 50 (12): 2504–15. Dec 2007. doi:10.1007/s00125-007-0835-5. PMID 17922104.
- "Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3". The Journal of Cell Biology 159 (2): 303–12. Oct 2002. doi:10.1083/jcb.200203074. PMID 12403815.
- "Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population". Diabetes 53 (8): 2122–5. Aug 2004. doi:10.2337/diabetes.53.8.2122. PMID 15277395.
- "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Human Molecular Genetics 18 (12): 2305–16. Jun 2009. doi:10.1093/hmg/ddp159. PMID 19336475.
- "Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects". Diabetologia 44 (2): 241–4. Feb 2001. doi:10.1007/s001250051606. PMID 11270683.
- "neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS". Molecular and Cellular Neurosciences 8 (4): 221–41. 1996. doi:10.1006/mcne.1996.0060. PMID 9000438.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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