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This article provides a list of autoimmune diseases . These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed with the condition. Each disorder is also categorized by its acceptance as an autoimmune condition into four levels: confirmed, probable, possible, and uncertain. This classification is based on the current scientific consensus and reflects the level of evidence supporting the autoimmune nature of the disorder. Lastly, the prevalence rate, specifically in the United States, is included to give a sense of how common each disorder is within the population.
Confirmed - Used for conditions that have strong, well-established evidence of autoimmune etiology.
Probable - Used for conditions where there is substantial evidence of autoimmune involvement, but the scientific consensus may not be as strong as for those in the 'confirmed' category.
Possible - Used for conditions that have some evidence pointing towards autoimmune involvement, but it's not yet clear or there is ongoing debate.
Uncertain - Used for conditions where the evidence of autoimmune involvement is limited or contested.
Integumentary system
The integumentary system, composed of the skin, hair, nails, and associated glands, serves as a protective barrier between the body and the environment. It also plays a critical role in regulating body temperature and maintaining fluid balance.
Disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disease
Prevalence rate (US)
Cit.
Alopecia areata
Hair follicles
None specific
Confirmed
2.1%
[1] [2]
Autoimmune angioedema
Skin
C1 inhibitor
Probable
Less than 5,000
[3]
Autoimmune progesterone dermatitis
Skin
Progesterone
Probable
Extremely rare
[4]
Autoimmune urticaria
Skin
IgG against IgE or IgE receptor
Probable
Not well established
[5] [6]
Bullous pemphigoid
Skin
Anti-BP180, Anti-BP230
Confirmed
6-30 per 100,000 (mostly older adults)
[7]
Cicatricial pemphigoid
Mucous membranes , sometimes skin
Anti-BP180, Anti-BP230
Confirmed
Rare
[8]
Dermatitis herpetiformis
Skin
Anti-tissue transglutaminase
Confirmed
10 per 100,000
[9]
Dermatomyositis
Skin and muscles
Anti-Jo1, Anti-Mi2, Anti-SRP, Anti-TIF1
Confirmed
9 in 1,000,000
[10]
Discoid lupus erythematosus
Skin
ANA, Anti-dsDNA, Anti-Sm
Confirmed
Part of SLE prevalence (20-150 per 100,000)
[11]
Epidermolysis bullosa acquisita
Skin
Anti-type VII collagen
Confirmed
Extremely rare
[12]
Erythema nodosum
Skin
None specific
Possible
Not well established
[13]
Gestational pemphigoid
Skin
Anti-BP180, Anti-BP230
Confirmed
Rare
[14]
Hidradenitis suppurativa
Skin
None specific
Uncertain
1-4%
[15]
Lichen planus
Skin, mucous membranes
None specific
Probable
1%
[16]
Lichen sclerosus
Skin
None specific
Probable
Rare
[17]
Linear IgA disease
Skin
Anti-epidermal basement membrane IgA
Confirmed
Extremely rare
[18]
Morphea
Skin
None specific
Probable
Not well established
[19]
Psoriasis
Skin
Various, not specific
Confirmed
2-3%
[20]
Pemphigus vulgaris
Skin and mucous membranes
Anti-desmoglein 3, Anti-desmoglein 1
Confirmed
1-5 per 100,000
[21]
Scleroderma (systemic sclerosis)
Skin, organs
ANA, anti-Scl-70, anti-centromere
Confirmed
240 per 1,000,000
[22]
Vitiligo
Skin
Various, not specific
Confirmed
1%
[23]
Digestive system
Autoimmune disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disease
Prevalence rate (US)
Cit.
Autoimmune enteropathy
Small intestine
Anti-enterocyte antibodies
Probable
Rare
[24]
Autoimmune hepatitis
Liver
ANA, ASMA, anti-LKM1
Confirmed
1 in 10,000 to 1 in 50,000
[25]
Celiac disease
Small intestine
Anti-tissue transglutaminase antibodies (tTG), Endomysial antibody (EMA), Deamidated gliadin peptide (DGP)
Confirmed
1 in 100
[26]
Crohn's disease
Digestive tract
ASCA, Anti-OmpC, Anti-CBir1, ANCA
Probable
201 per 100,000 adults
[27]
Pernicious anemia
Stomach
Anti-IF, Anti-parietal cell
Confirmed
0.1%
[28]
Ulcerative colitis
Colon and rectum
pANCA, ASCA
Probable
249 per 100,000 adults
[29]
Heart and vascular system
Autoimmune disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disease
Prevalence rate (US)
Cit.
Rheumatic heart disease
Heart valves
Anti-streptolysin O (ASO), anti-DNase B
Confirmed
Declining due to improved treatment of strep throat
[30]
Kawasaki disease
Coronary arteries
Unknown
Probable
20 per 100,000 children under age 5
[31]
Giant cell arteritis
Large and medium arteries, can affect coronary arteries
None specific
Confirmed
200 per 100,000 (over age 50)
[32] [33]
Takayasu's arteritis
Large arteries, including the aorta
None specific
Confirmed
Rare, more common in East Asia
[33] [34]
Behçet's disease
Small to large vessels in mouth, genitals, eyes, skin
None specific
Probable
[35]
Eosinophilic granulomatosis with polyangiitis (EGPA)
Small to medium vessels in respiratory tract, skin, heart, kidneys, nerves
ANCA
Confirmed
[36]
Granulomatosis with polyangiitis (GPA)
Small to medium vessels in respiratory tract, kidneys
c-ANCA/PR3-ANCA
Confirmed
[36]
IgA vasculitis (IgAV)
Small vessels in skin, joints, kidneys, gastrointestinal tract
IgA immune complexes
Probable
[37]
Leukocytoclastic vasculitis
Small vessels in skin
Various immune complexes
Probable
[38]
Lupus vasculitis
Small to medium vessels in multiple organs
ANA, anti-dsDNA, anti-Smith, others
Confirmed
[39]
Rheumatoid vasculitis
Small to medium vessels in skin, nerves, eyes, heart
Rheumatoid factor, ACPA
Probable
[40]
Microscopic polyangiitis (MPA)
Small vessels in kidneys, lungs, nerves, skin
p-ANCA/MPO-ANCA
Confirmed
[41]
Polyarteritis nodosa (PAN)
Medium to small vessels in kidneys, skin, muscles, joints, nerves
None specific
Probable
[42]
Polymyalgia rheumatica
Large to medium vessels in shoulders, hips
None specific
Possible
[43]
Urticarial vasculitis
Small vessels in skin
C1q antibodies
Probable
[44]
Vasculitis
All vessel sizes in multiple organs
Depends on specific type
Uncertain
[45]
Urinary system
Autoimmune disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disease
Prevalence rate (US)
Cit.
Goodpasture syndrome
Kidneys, lungs
Anti-GBM antibodies
Confirmed
1 per million people
[46]
IgA nephropathy
Kidneys
IgA autoantibodies
Confirmed
3.5 per 100,000
[47]
Membranous nephropathy
Kidneys
Anti-PLA2R antibodies
Confirmed
10 per 100,000
[48]
Lupus nephritis
Kidneys
Anti-dsDNA, Anti-Sm, Anti-nuclear antibodies
Confirmed
Up to 60% of those with Lupus
[49]
Interstitial nephritis
Kidneys
Various autoantibodies
Probable
Varies widely, often drug-induced
[50]
Interstitial cystitis
Bladder
Anti-urothelial and anti-nuclear antibodies
Probable
100-450 per 100,000 women, less common in men
[51]
Primary sclerosing cholangitis
Bile ducts, can affect gallbladder
ANCA, Anti-mitochondrial antibodies
Confirmed
1 per 100,000
[52]
Nervous system
Autoimmune disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disease
Prevalence rate (US)
Cit.
Acute disseminated encephalomyelitis
Central nervous system
Unknown
Confirmed
0.8 per 100,000
[53]
Acute motor axonal neuropathy
Peripheral nerves
Anti-GM1
Confirmed
Part of Guillain-Barré syndrome prevalence
Anti-NMDA receptor encephalitis
Brain
Anti-NMDA receptor
Confirmed
1.5 per million
[54]
Autoimmune encephalitis
Brain
Various, depending on subtype (e.g., NMDA receptor antibodies, LGI1 antibodies)
Confirmed
Rare
[55]
Balo concentric sclerosis
Central nervous system
Unknown
Probable
Rare
[56]
Bickerstaff's encephalitis
Brain
Anti-GQ1b
Confirmed
Rare
[57]
Chronic inflammatory demyelinating polyneuropathy
Peripheral nerves
Various, including anti-MAG
Confirmed
1-2 per 100,000
[58]
Guillain-Barré syndrome
Peripheral nerves
Various, including anti-GM1, anti-GD1a
Confirmed
1-2 per 100,000
[59]
Hashimoto's encephalopathy
Brain
Anti-thyroid (TPO, Tg)
Probable
Rare
[60]
Idiopathic inflammatory demyelinating diseases
Central nervous system
Varies
Probable
Varies by specific disease
[61]
Lambert–Eaton myasthenic syndrome
Neuromuscular junction (affecting both CNS and PNS)
Anti-VGCC
Confirmed
0.5-2 per million
[62]
Multiple sclerosis
Central nervous system
Unknown, but Oligoclonal bands often present in CSF
Confirmed
90 per 100,000
[63]
Myasthenia gravis
Neuromuscular junction (affecting both CNS and PNS)
Anti-AChR, anti-MuSK
Confirmed
20 per 100,000
[64]
Neuromyelitis optica (Devic's disease)/NMOSD
Optic nerves and spinal cord
AQP4-IgG (NMO-IgG)
Confirmed
0.5 - 4 per 100,000
[65]
Restless legs syndrome
Central nervous system (thought to involve dopaminergic pathways)
Unknown
Uncertain
5-15% (more common in older adults)
[66]
Stiff-person syndrome
Central nervous system
Anti-GAD, anti-amphiphysin
Confirmed
Rare
[67]
Sydenham's chorea
Brain
Anti-basal ganglia
Confirmed
Rare (linked to Group A streptococcal infection)
[68]
Transverse myelitis
Spinal cord
Various, including anti-AQP4
Probable
1-8 per million
[69]
Undifferentiated connective tissue disease (UCTD)
Various
ANA (antinuclear autoantibody) (HEp-2 cells)
Confirmed
2 per 100,000
[70]
Endocrine system
Autoimmune disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disease
Prevalence rate (US)
Cit.
Addison's disease
Adrenal glands
21-hydroxylase antibodies
Confirmed
0.93-1.4 per 10,000
[71]
Autoimmune oophoritis
Ovaries
Anti-ovarian antibodies
Probable
Rare
[72]
Autoimmune orchitis
Testes
Anti-sperm antibodies
Probable
Rare
[73]
Autoimmune pancreatitis
Pancreas
IgG4, Anti-CA2 antibodies
Confirmed
0.82-1.3 per 100,000
[74]
Autoimmune polyendocrine syndrome type 1 (APS1)
Multiple endocrine organs
Various autoantibodies depending on the organs affected
Confirmed
1 in 100,000 to 200,000
[75]
Autoimmune polyendocrine syndrome type 2 (APS2)
Multiple endocrine organs
Various autoantibodies depending on the organs affected
Confirmed
1 in 20,000
[76]
Autoimmune polyendocrine syndrome type 3 (APS3)
Multiple endocrine organs
Various autoantibodies depending on the organs affected
Confirmed
Rare
[76]
Diabetes mellitus type 1
Pancreas
Anti-insulin, anti-IA-2, anti-GAD, anti-ZnT8 antibodies
Confirmed
1.6 per 1,000
[77]
Endometriosis
Endometrium
Anti-endometrial antibodies
Probable
6-10% of women of reproductive age
[78]
Graves' disease
Thyroid gland
TSI, TPO, TG antibodies
Confirmed
1.2% of the population
[79]
Hashimoto's thyroiditis
Thyroid gland
TPO, TG antibodies
Confirmed
5% of the population
[80]
Ord's thyroiditis
Thyroid gland
TPO, TG antibodies
Confirmed
Rare
[81]
Sjögren syndrome
Exocrine glands (salivary and lacrimal glands)
Anti-SSA/Ro, Anti-SSB/La antibodies
Confirmed
0.1-4% of the population
[82]
Respiratory system
Blood
Reproductive system
The reproductive system is responsible for the production and regulation of sex hormones, the formation of germ cells, and the nurturing of fertilized eggs. In women, it includes structures such as ovaries, fallopian tubes, a uterus, and a vagina, while in men, it includes testes, vas deferens, seminal vesicles, prostate, and the penis. Autoimmune diseases of the reproductive system can affect both male and female fertility and reproductive health.
Autoimmune disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disease
Prevalence rate (US)
Cit.
Autoimmune orchitis
Testes
Anti-sperm antibodies
Probable
Not well established
[93]
Autoimmune oophoritis
Ovaries
Anti-ovarian antibodies
Probable
Not well established
[93]
Endometriosis
Uterus , ovaries, and pelvic tissue
Various, including anti-endometrial antibodies
Probable
Approx. 10% of women of reproductive age
[94]
Premature ovarian failure
Ovaries
Anti-ovarian antibodies, Anti-adrenal antibodies
Confirmed
1% of women under 40 years
[95]
Eyes
Muscular system
These autoimmune diseases are primarily associated with the muscles and neuromuscular function.
Autoimmune disease
Primary organ/body part affected
Autoantibodies
Acceptance as an autoimmune disorder
Prevalence rate (US)
Cit.
Dermatomyositis
See integumentary system [lower-alpha 4]
See integumentary system
Confirmed
See integumentary system
N/A
Fibromyalgia
Musculoskeletal system, pain perception
None specific
Possible
[110]
Inclusion body myositis
Proximal and distal muscles
None specific
Probable
[111]
Myositis
Skeletal muscles
Various, depends on subtype
Confirmed
[112]
Myasthenia gravis
Voluntary muscles, neuromuscular junctions
Anti-acetylcholine receptor, Anti-MuSK
Confirmed
[113]
Neuromyotonia
Peripheral nerves affecting muscle control
Anti-voltage-gated potassium channels
Probable
[114]
Paraneoplastic cerebellar degeneration
Central nervous system, cerebellum
Anti-Yo, Anti-Hu, Anti-Ri, others
Confirmed
[115]
Polymyositis
Proximal skeletal muscles
Anti-Jo-1, Anti-SRP, others
Confirmed
[116]
Autoimmune comorbidities
This list includes conditions that are not diseases, but symptoms or syndromes common to autoimmune disease.[117]
Non-autoimmune
At this time, there is not sufficient evidence to indicate that these diseases are caused by autoimmunity .
Disease
Reason not believed to be autoimmune
Cit.
Agammaglobulinemia
An immune system disorder but not an autoimmune disease.
Amyloidosis
No consistent evidence of association with autoimmunity.
Amyotrophic lateral sclerosis
No consistent evidence of association with autoimmunity.
Anti-tubular basement membrane nephritis
No consistent evidence of association with autoimmunity.
Atopic allergy
A hypersensitivity.
Atopic dermatitis
A hypersensitivity.
Autism
No consistent evidence of association with maternal autoimmunity.
Blau syndrome
Overlaps both sarcoidosis and granuloma annulare. No evidence of association with autoimmunity.
Cancer
No consistent evidence of association with autoimmunity.
Castleman's disease
An immune system disorder but not an autoimmune disease.
Chagas disease
No consistent evidence of association with autoimmunity.
[120]
Chronic obstructive pulmonary disease
No consistent evidence of association with autoimmunity.
[121] [122]
Chronic recurrent multifocal osteomyelitis
LPIN2, D18S60. Synonyms: Majeed syndrome.
Complement component 2 deficiency
Possibly symptomatic of autoimmune diseases, but not a disease.
Congenital heart block
May be related to autoimmune activity in the mother.
Contact dermatitis
A hypersensitivity.
Cushing's syndrome
No consistent evidence of association with autoimmunity.
Cutaneous leukocytoclastic angiitis
No consistent evidence of association with autoimmunity.
Dego's disease
No consistent evidence of association with autoimmunity.
Eosinophilic gastroenteritis
Possibly a hypersensitivity.
Eosinophilic pneumonia
A class of diseases, some of which may be autoimmune.
Erythroblastosis fetalis
Mother's immune system attacks fetus. An immune system disorder but not autoimmune.
Fibrodysplasia ossificans progressiva
Possibly an immune system disorder but not autoimmune.
Gastrointestinal pemphigoid
No consistent evidence of association with autoimmunity.
Hypogammaglobulinemia
An immune system disorder but not autoimmune.
Idiopathic giant-cell myocarditis
No consistent evidence of autoimmune cause though the disease has been found comorbid with other autoimmune diseases.
[123]
Idiopathic pulmonary fibrosis
Autoantibodies: SFTPA1, SFTPA2, TERT, and TERC.
IgA nephropathy
An immune system disorder but not an autoimmune disease.
IPEX syndrome
A genetic mutation in FOXP3 that leads to autoimmune diseases, but not an autoimmune disorder itself.
Ligneous conjunctivitis
No consistent evidence of association with autoimmunity.
Majeed syndrome
No consistent evidence of association with autoimmunity.
Narcolepsy
No evidence of association with autoimmunity. Research not reproducible.
Rasmussen's encephalitis
No consistent evidence of association with autoimmunity.
Schizophrenia
No consistent evidence of association with autoimmunity.
Serum sickness
A hypersensitivity.
Spondyloarthropathy
No consistent evidence of association with autoimmunity.
Sweet's syndrome
No consistent evidence of association with autoimmunity.
Takayasu's arteritis
No consistent evidence of association with autoimmunity.
Undifferentiated spondyloarthropathy
See also
Notes
↑ For detailed information on Goodpasture syndrome, including its impact on the respiratory system, refer to its entry in the urinary system section.
↑ For detailed information on EGPA, including its impact on the respiratory system, refer to its entry in the vascular system section.
↑ For detailed information on GPA, including its impact on the respiratory system, refer to its entry in the vascular system section.
↑ For detailed information on dermatomyositis, including its impact on the musclar system, refer to its entry in the integumentary system section.
References
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External links
Original source: https://en.wikipedia.org/wiki/List of autoimmune diseases. Read more