Biology:Hemagglutinin-neuraminidase
| Hemagglutinin-neuraminidase, Paramyxoviridae | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of the sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | HN | ||||||||||
| Pfam | PF00423 | ||||||||||
| Pfam clan | CL0434 | ||||||||||
| InterPro | IPR000665 | ||||||||||
| SCOP2 | 1usr / SCOPe / SUPFAM | ||||||||||
| CAZy | GH83 | ||||||||||
| CDD | cd15469 | ||||||||||
| |||||||||||
Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins. Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83).[2]
It does show a structural similarity to influenza viral neuraminidase and has a six-bladed beta-propeller structure.[3] This Pfam entry also matches measles hemagglutinin (cd15467), which has a "dead" neuraminidase part repurposed as a receptor binding site.[4]
Hemagglutinin-neuraminidase allows the virus to stick to a potential host cell, and cut itself loose if necessary. Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses including mumps virus, human parainfluenza virus 3, and the avian pathogen Newcastle disease virus.
Types include:
- Mumps hemagglutinin-neuraminidase
- Parainfluenza hemagglutinin-neuraminidase
Hemagglutinin-neuraminidase inhibitors have been investigated and suggest that there may applications for human use in the future.[5]
References
- ↑ "Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion". J. Virol. 78 (7): 3733–41. April 2004. doi:10.1128/JVI.78.7.3733-3741.2004. PMID 15016893.
- ↑ "Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.". Structure 13 (5): 803–15. 2005. doi:10.1016/j.str.2005.02.019. PMID 15893670.
- ↑ "Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III". J. Mol. Biol. 335 (5): 1343–57. January 2004. doi:10.1016/j.jmb.2003.11.032. PMID 14729348.
- ↑ Colf, LA; Juo, ZS; Garcia, KC (December 2007). "Structure of the measles virus hemagglutinin.". Nature Structural & Molecular Biology 14 (12): 1227–8. doi:10.1038/nsmb1342. PMID 18026116.
- ↑ "Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in vivo". Antimicrob. Agents Chemother. 48 (5): 1495–502. May 2004. doi:10.1128/AAC.48.5.1495-1502.2004. PMID 15105096.
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