Biology:TTK (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene.[1][2]
References
- ↑ "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem 267 (22): 16000–6. Aug 1992. doi:10.1016/S0021-9258(19)49633-6. PMID 1639825.
- ↑ "Entrez Gene: TTK TTK protein kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7272.
Further reading
- "Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members". Protein Phosphorylation Part A: Protein Kinases: Assays, Purification, Antibodies, Functional Analysis, Cloning, and Expression. Methods in Enzymology. 200. 1991. 38–62. doi:10.1016/0076-6879(91)00126-H. ISBN 978-0-12-182101-2.
- "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene 8 (2): 351–9. 1993. PMID 7678926.
- Lauzé E; Stoelcker B; Luca FC et al. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. doi:10.1002/j.1460-2075.1995.tb07154.x. PMID 7737118.
- Cahill DP; da Costa LT; Carson-Walter EB et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
- Weinmann AS; Yan PS; Oberley MJ et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMID 11799066.
- "Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication". EMBO J. 21 (7): 1723–32. 2002. doi:10.1093/emboj/21.7.1723. PMID 11927556.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Liu ST; Chan GK; Hittle JC et al. (2003). "Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores". Mol. Biol. Cell 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMID 12686615.
- "Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 14875–80. 2004. doi:10.1073/pnas.2434156100. PMID 14657364.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dou Z; Ding X; Zereshki A et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.
- Wei JH; Chou YF; Ou YH et al. (2005). "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68". J. Biol. Chem. 280 (9): 7748–57. doi:10.1074/jbc.M410152200. PMID 15618221.
- Camacho E; Beà S; Salaverría I et al. (2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer 118 (2): 357–63. doi:10.1002/ijc.21370. PMID 16080195.
- Leng M; Chan DW; Luo H et al. (2006). "MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11485–90. doi:10.1073/pnas.0601828103. PMID 16864798. Bibcode: 2006PNAS..10311485L.
- Bertheau P; Turpin E; Rickman DS et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMID 17388661.
- "Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling". J. Biol. Chem. 282 (25): 18327–38. 2007. doi:10.1074/jbc.M700636200. PMID 17452325.
- Kanai M; Ma Z; Izumi H et al. (2007). "Physical and functional interaction between mortalin and Mps1 kinase". Genes Cells 12 (6): 797–810. doi:10.1111/j.1365-2443.2007.01091.x. PMID 17573779.
- Mattison CP; Old WM; Steiner E et al. (2007). "Mps1 activation loop autophosphorylation enhances kinase activity". J. Biol. Chem. 282 (42): 30553–61. doi:10.1074/jbc.M707063200. PMID 17728254.
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