Biology:UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
From HandWiki
Short description: Class of enzymes
| UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.115 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115, FlaA1, UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase, PseB, UDP-N-acetylglucosamine hydro-lyase (inverting, UDP-2-acetamido-2,6-dideoxy-β-L)arabino-hex-4-ulose-forming)) is an enzyme with systematic name UDP-N-acetyl-α-D-glucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-α-D-glucosamine [math]\displaystyle{ \rightleftharpoons }[/math] UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose + H2O
This enzyme contains NADP+ as a cofactor.
References
- ↑ "Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity". The Journal of Biological Chemistry 281 (34): 24489–95. August 2006. doi:10.1074/jbc.m602393200. PMID 16651261.
- ↑ "Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori". Molecular Microbiology 48 (6): 1579–92. June 2003. doi:10.1046/j.1365-2958.2003.03527.x. PMID 12791140.
- ↑ "Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction". Glycobiology 16 (9): 8C-14C. September 2006. doi:10.1093/glycob/cwl010. PMID 16751642.
External links
- UDP-N-acetylglucosamine+4,6-dehydratase+(configuration-inverting) at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
