Chemistry:5-Fluoro-MET

Short description: Chemical compound

5-Fluoro-MET

Clinical data
Other names	5F-MET
Identifiers
IUPAC name N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethanamine
PubChem CID	156836209
Chemical and physical data
Formula	C13H17FN2
Molar mass	220.291 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(C)CCC1=CNC2=C1C=C(C=C2)F
InChI InChI=1S/C13H17FN2/c1-3-16(2)7-6-10-9-15-13-5-4-11(14)8-12(10)13/h4-5,8-9,15H,3,6-7H2,1-2H3 Key:XRWQULAXCLVBPP-UHFFFAOYSA-N

5-Fluoro-MET (5F-MET, 5-fluoro-N-methyl-N-ethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-Fluoro-DMT and N-Methyl-N-ethyltryptamine (MET). It acts as an agonist at the 5-HT_2A receptor with an EC₅₀ of 20.6 nM and produces a head-twitch response in animal studies. Ring fluorination in this case increases efficacy at 5-HT_2A, with 5F-MET having an efficacy of 87.6% vs 5-HT, vs 36.2% for the partial agonist MET. It is claimed to have antidepressant activity.

See also

• 5-Fluoro-AMT
• 5-Fluoro-AET
• 5-Fluoro-DET
• 5-Fluoro-EPT
• 5-MeO-MET
• 7-F-5-MeO-MET