Biology:LMX1A
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LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[1][2]
Function
Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[3]
Interactions
LMX1A has been shown to interact with TCF3[4] and LHX3.[5]
References
- ↑ "Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4009.
- ↑ "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics 24 (2): 403–4. November 1994. doi:10.1006/geno.1994.1639. PMID 7698771.
- ↑ "Entrez Gene: LMX1A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4009.
- ↑ "Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity". Mol. Cell. Biol. 17 (7): 3488–96. Jul 1997. doi:10.1128/mcb.17.7.3488. PMID 9199284.
- ↑ "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. Feb 1998. doi:10.1074/jbc.273.6.3152. PMID 9452425.
Further reading
- "Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex". Genes Dev. 6 (11): 2165–76. 1992. doi:10.1101/gad.6.11.2165. PMID 1358758.
- "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics 24 (2): 403–4. 1994. doi:10.1006/geno.1994.1639. PMID 7698771.
- "Functional analysis of the nuclear LIM domain interactor NLI". Mol. Cell. Biol. 17 (10): 5688–98. 1997. doi:10.1128/MCB.17.10.5688. PMID 9315627.
- "Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9". Genomics 46 (3): 520–4. 1997. doi:10.1006/geno.1997.5075. PMID 9441763.
- "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. 1998. doi:10.1074/jbc.273.6.3152. PMID 9452425.
- "Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians". Gene 290 (1–2): 217–25. 2002. doi:10.1016/S0378-1119(02)00582-6. PMID 12062816.
- "Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse". Dev. Biol. 270 (2): 382–92. 2004. doi:10.1016/j.ydbio.2004.03.008. PMID 15183721.
- "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics 4 (5): 1346–58. 2004. doi:10.1002/pmic.200300770. PMID 15188402.
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