Biology:Secretin receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the secretin receptor family, also called class B GPCR subfamily.

Interactions

The secretin receptor has been shown to interact with pituitary adenylate cyclase activating peptide.

Further reading

• "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology 114 (2): 382–97. February 1998. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500. 
• "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology 263 (6 Pt 1): G901-7. December 1992. doi:10.1152/ajpgi.1992.263.6.G901. PMID 1335692. 
• "Molecular cloning and expression of a cDNA encoding the secretin receptor". The EMBO Journal 10 (7): 1635–41. July 1991. doi:10.1002/j.1460-2075.1991.tb07686.x. PMID 1646711. 
• "Secretin receptors in human pancreatic membranes". Pancreas 3 (5): 529–35. 1988. doi:10.1097/00006676-198810000-00004. PMID 3186683. 
• "Molecular cloning and functional characterization of a human secretin receptor". Biochemical and Biophysical Research Communications 212 (1): 204–11. July 1995. doi:10.1006/bbrc.1995.1957. PMID 7612008. 
• "Molecular cloning and expression of a human secretin receptor". Molecular Pharmacology 47 (3): 467–73. March 1995. PMID 7700244. 
• "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". The Journal of Biological Chemistry 270 (24): 14394–8. June 1995. doi:10.1074/jbc.270.24.14394. PMID 7782300. 
• "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochemical and Biophysical Research Communications 207 (3): 883–90. February 1995. doi:10.1006/bbrc.1995.1268. PMID 7864894. 
• "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochemical and Biophysical Research Communications 193 (2): 546–53. June 1993. doi:10.1006/bbrc.1993.1658. PMID 8390245. 
• "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics 29 (3): 817–8. October 1995. doi:10.1006/geno.1995.9922. PMID 8575789. 
• "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochemical and Biophysical Research Communications 218 (3): 842–6. January 1996. doi:10.1006/bbrc.1996.0150. PMID 8579602. 
• "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & Signal Transduction 7 (3): 143–50. 1998. PMID 9440501. 
• "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". The Journal of Biological Chemistry 273 (12): 6756–62. March 1998. doi:10.1074/jbc.273.12.6756. PMID 9506976. 
• "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Letters 455 (3): 209–14. July 1999. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774. 
• "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology 140 (11): 5102–11. November 1999. doi:10.1210/endo.140.11.7134. PMID 10537138. 
• "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology 142 (9): 3926–34. September 2001. doi:10.1210/endo.142.9.8389. PMID 11517171. 
• "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Molecular Endocrinology 18 (2): 471–83. February 2004. doi:10.1210/me.2003-0245. PMID 14645499. 

External links

• IUPHAR GPCR Database - Secretin receptor
• secretin+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)