Biology:POM121
 Generic protein structure example |
Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene.[1][2][3] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[4]
Function
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope.[4]
Antibodies against this protein can be used to identify the nuclear envelope in immunofluorescence experiments.[5]
References
- ↑ "An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region". J Cell Biol 122 (3): 513–21. Aug 1993. doi:10.1083/jcb.122.3.513. PMID 8335683.
- ↑ "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. Dec 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ↑ "Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes". FEBS Lett 581 (25): 4910–6. Oct 2007. doi:10.1016/j.febslet.2007.09.021. PMID 17900573.
- ↑ 4.0 4.1 "Entrez Gene: POM121 POM121 membrane glycoprotein (homo sapiens)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9883.
- ↑ "Sequential degradation of proteins from the nuclear envelope during apoptosis". J. Cell Sci. 114 (Pt 20): 3643–53. October 2001. doi:10.1242/jcs.114.20.3643. PMID 11707516.
Further reading
- "Function and assembly of nuclear pore complex proteins". Biochem. Cell Biol. 77 (4): 321–9. 1999. doi:10.1139/bcb-77-4-321. PMID 10546895.
- "POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue". Genomics 25 (2): 354–9. 1995. doi:10.1016/0888-7543(95)80033-I. PMID 7789967. https://zenodo.org/record/1258599.
- "Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex". J. Virol. 72 (7): 6004–13. 1998. doi:10.1128/JVI.72.7.6004-6013.1998. PMID 9621063.
- "Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells". J. Cell Biol. 154 (1): 71–84. 2001. doi:10.1083/jcb.200101089. PMID 11448991.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Dynamic properties of nuclear pore complex proteins in gp210 deficient cells". FEBS Lett. 572 (1–3): 261–5. 2004. doi:10.1016/j.febslet.2004.07.044. PMID 15304359.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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