Biology:ZFYVE27

Generic protein structure example

Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene.

Function

This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote Neurite formation. A mutation in this gene has been reported to be associated with Hereditary spastic paraplegia, however the Pathogenicity of the mutation, which may simply represent a Polymorphism, is unclear. [provided by RefSeq, Mar 2010].

Further reading

• "Role of spastin and protrudin in neurite outgrowth". Journal of Cellular Biochemistry 113 (7): 2296–307. July 2012. doi:10.1002/jcb.24100. PMID 22573551. 
• "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein". The Journal of Biological Chemistry 284 (20): 13766–77. May 2009. doi:10.1074/jbc.M807938200. PMID 19289470. 
• "ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia". American Journal of Human Genetics 79 (2): 351–7. August 2006. doi:10.1086/504927. PMID 16826525. 
• "The role of ZFYVE27/protrudin in hereditary spastic paraplegia". American Journal of Human Genetics 83 (1): 127–8; author reply 128–30. July 2008. doi:10.1016/j.ajhg.2008.05.014. PMID 18606302. 
• "Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation". Molecular Biology of the Cell 22 (23): 4602–20. December 2011. doi:10.1091/mbc.E11-01-0068. PMID 21976701. 
• "Protrudin induces neurite formation by directional membrane trafficking". Science 314 (5800): 818–21. November 2006. doi:10.1126/science.1134027. PMID 17082457. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.