Biology:SLCO2A1
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Solute carrier organic anion transporter family, member 2A1 also known as the prostaglandin transporter (PGT) is a protein that in humans is encoded by the SLCO2A1 gene.[1]
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[1]
Clinical relevance
Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=6578. Retrieved 2011-12-30.
- ↑ "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy". American Journal of Human Genetics 90 (1): 125–32. January 2012. doi:10.1016/j.ajhg.2011.11.019. PMID 22197487.
Further reading
- "Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties". Pflügers Archiv 447 (5): 653–65. February 2004. doi:10.1007/s00424-003-1168-y. PMID 14579113.
- "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenetics and Genomics 15 (1): 43–50. January 2005. doi:10.1097/01213011-200501000-00007. PMID 15864125.
- "Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells". Human Reproduction 21 (3): 592–9. March 2006. doi:10.1093/humrep/dei400. PMID 16339169.
- "Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls". Journal of Neuroimmunology 195 (1-2): 81–7. March 2008. doi:10.1016/j.jneuroim.2008.01.014. PMID 18353443.
- "Regulation of prostaglandin transporters in colorectal neoplasia". Cancer Prevention Research 1 (2): 93–9. July 2008. doi:10.1158/1940-6207.CAPR-07-0009. PMID 19138942.
- "The prostaglandin transporter PGT transports PGH(2)". Biochemical and Biophysical Research Communications 395 (2): 168–72. April 2010. doi:10.1016/j.bbrc.2010.03.108. PMID 20346915.
- "Differential expression of the enzymatic system controlling synthesis, metabolism, and transport of PGF2 alpha in human fetal membranes". Biology of Reproduction 83 (1): 155–62. July 2010. doi:10.1095/biolreprod.109.080390. PMID 20357271.
- "Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)". The Journal of Clinical Investigation 98 (5): 1142–9. September 1996. doi:10.1172/JCI118897. PMID 8787677.
- "Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization". Biochemical and Biophysical Research Communications 246 (3): 805–12. May 1998. doi:10.1006/bbrc.1998.8715. PMID 9618293.
- "Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo". Circulation 98 (22): 2396–403. December 1998. doi:10.1161/01.CIR.98.22.2396. PMID 9832484.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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