Biology:HOXD10

Short description: Protein-coding gene in humans

Generic protein structure example

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.

Regulation

The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.

See also

• Homeobox

Further reading

• "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature 449 (7163): 682–8. Oct 2007. doi:10.1038/nature06174. PMID 17898713. Bibcode: 2007Natur.449..682M. 
• "Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs". Development 116 (2): 289–96. Oct 1992. doi:10.1242/dev.116.2.289. PMID 1363084. 
• "Limb malformations and the human HOX genes". American Journal of Medical Genetics 112 (3): 256–65. Oct 2002. doi:10.1002/ajmg.10776. PMID 12357469. 
• "Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts". Genomics 13 (2): 425–30. Jun 1992. doi:10.1016/0888-7543(92)90263-R. PMID 1351871. 
• "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. Nov 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
• "HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities". The EMBO Journal 10 (13): 4177–87. Dec 1991. doi:10.1002/j.1460-2075.1991.tb04996.x. PMID 1756725. 
• "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Jul 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
• "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–9. Oct 1990. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852. 
• "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652. 
• "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal 13 (14): 3339–47. Jul 1994. doi:10.1002/j.1460-2075.1994.tb06636.x. PMID 7913891. 
• "Expression of AbdB-type homeobox genes in human tumors". Laboratory Investigation; A Journal of Technical Methods and Pathology 71 (5): 663–70. Nov 1994. PMID 7967520. 
• "Autosomal dominant tetramelic postaxial oligodactyly". American Journal of Medical Genetics 46 (5): 579–83. Jun 1993. doi:10.1002/ajmg.1320460524. PMID 8100684. 
• "Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma". Journal of the Society for Gynecologic Investigation 5 (5): 277–80. 1998. doi:10.1016/S1071-5576(98)00020-3. PMID 9773404. 
• "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". American Journal of Human Genetics 65 (1): 104–10. Jul 1999. doi:10.1086/302467. PMID 10364522. 
• "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. Nov 1999. doi:10.1128/mcb.19.11.7577. PMID 10523646. 
• "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenetics and Cell Genetics 90 (1–2): 151–3. 2000. doi:10.1159/000015651. PMID 11060466. 
• "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology 21 (21): 7509–22. Nov 2001. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930. 
• "A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly". American Journal of Human Genetics 70 (2): 547–55. Feb 2002. doi:10.1086/338921. PMID 11778160. 
• "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506. 

External links

• HOXD10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.