Biology:IRF2BP2 (gene)

Generic protein structure example

Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene.

Function

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Further reading

• "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2". Nucleic Acids Res. 31 (12): 3016–26. 2003. doi:10.1093/nar/gkg431. PMID 12799427. 
• "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells". Cancer Res. 69 (4): 1375–82. 2009. doi:10.1158/0008-5472.CAN-08-2896. PMID 19190336. 
• "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. 2010. doi:10.1096/fj.10-167049. PMID 20702774. 
• "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. 2010. doi:10.1096/fj.10-167049. PMID 20702774. 
• "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity". Mol. Cell. Biol. 31 (14): 2889–901. 2011. doi:10.1128/MCB.00974-10. PMID 21576369. 
• "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2". PLOS ONE 6 (8): e24100. 2011. doi:10.1371/journal.pone.0024100. PMID 21887377. Bibcode: 2011PLoSO...624100T. 
• "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". PLOS ONE 7 (11): e49705. 2012. doi:10.1371/journal.pone.0049705. PMID 23185413. Bibcode: 2012PLoSO...749705N. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.