Biology:TRIM33
 Generic protein structure example |
E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.[1] [2]
TRIM33 is thought to be a transcriptional corepressor. However unlike the related TRIM24 and TRIM28 proteins, few transcription factors such as SMAD4 that interact with TRIM33 have been identified.[3]
Structure
The protein is a member of the tripartite motif family.[4] This motif includes three zinc-binding domains:
- RING
- B-box type 1 zinc finger
- B-box type 2 zinc finger
and a coiled-coil region.
Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.[3]
Interactions
TRIM33 has been shown to interact with TRIM24.[5]
Role in cancer
TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.[6] TRIM33 regulates also the TRIM28 receptor and promotes physiological aging of hematopoietic stem cells. [7] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.[8]
References
- ↑ "UniProt". https://www.uniprot.org/uniprotkb/Q9UPN9/entry#names_and_taxonomy.
- ↑ "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene 18 (5): 1209–17. February 1999. doi:10.1038/sj.onc.1202655. PMID 10022127.
- ↑ 3.0 3.1 "Entrez Gene: TRIM33 tripartite motif-containing 33". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51592.
- ↑ "The tripartite motif family identifies cell compartments". The EMBO Journal 20 (9): 2140–51. May 2001. doi:10.1093/emboj/20.9.2140. PMID 11331580.
- ↑ "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology 320 (3): 629–44. July 2002. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
- ↑ "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". The Journal of Clinical Investigation 121 (6): 2361–70. June 2011. doi:10.1172/JCI45213. PMID 21537084.
- ↑ "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proceedings of the National Academy of Sciences of the United States of America 111 (29): 10592–7. July 2014. doi:10.1073/pnas.1405546111. PMID 25002492. Bibcode: 2014PNAS..11110592Q.
- ↑ "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife 4: e06377. April 2015. doi:10.7554/eLife.06377. PMID 25919951.
Further reading
- "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene 18 (5): 1209–17. February 1999. doi:10.1038/sj.onc.1202655. PMID 10022127.
- "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas". Oncogene 18 (30): 4388–93. July 1999. doi:10.1038/sj.onc.1202824. PMID 10439047.
- "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (3): 197–205. June 1999. doi:10.1093/dnares/6.3.197. PMID 10470851.
- "The tripartite motif family identifies cell compartments". The EMBO Journal 20 (9): 2140–51. May 2001. doi:10.1093/emboj/20.9.2140. PMID 11331580.
- "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology 320 (3): 629–44. July 2002. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
- "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell 12 (3): 723–34. September 2003. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. June 2004. doi:10.1038/nbt971. PMID 15146197.
- "Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase". Cell 121 (1): 87–99. April 2005. doi:10.1016/j.cell.2005.01.033. PMID 15820681.
- "Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway". Cell 125 (5): 929–41. June 2006. doi:10.1016/j.cell.2006.03.045. PMID 16751102.
External links
- TRIM33+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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