Biology:VWA2
 Generic protein structure example |
von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.[1][2]
AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.[2] AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.[3]
AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction,[4] the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in colon cancers;[5] indicating that it might be a good candidate as a biomarker for this type of cancer.
References
- ↑ "Entrez Gene: von Willebrand factor A domain containing 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340706.
- ↑ 2.0 2.1 "Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". The Journal of Biological Chemistry 278 (50): 50240–9. December 2003. doi:10.1074/jbc.M307794200. PMID 14506275.
- ↑ "Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment". Matrix Biology 28 (8): 456–62. October 2009. doi:10.1016/j.matbio.2009.07.006. PMID 19651211.
- ↑ "AMACO is a component of the basement membrane-associated Fraser complex". The Journal of Investigative Dermatology 134 (5): 1313–1322. May 2014. doi:10.1038/jid.2013.492. PMID 24232570.
- ↑ "Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia". Oncogene 24 (4): 724–31. January 2005. doi:10.1038/sj.onc.1208134. PMID 15580307.
Further reading
- "IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family". Annals of the New York Academy of Sciences 1037 (1): 145–9. December 2004. doi:10.1196/annals.1337.024. PMID 15699509. Bibcode: 2004NYASA1037..145E.
- "O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein)". The Journal of Biological Chemistry 283 (26): 17846–54. June 2008. doi:10.1074/jbc.M704820200. PMID 18434322.
External links
- VWA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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