Chemistry:AM-1714

From HandWiki
Short description: Chemical compound
AM-1714
AM-1714 structure.png
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC22H26O4
Molar mass354.446 g·mol−1
3D model (JSmol)

AM-1714 (part of the AM cannabinoid series) is a drug that acts as a reasonably selective agonist of the peripheral cannabinoid receptor CB2, with sub-nanomolar affinity and 490x selectivity over the related CB1 receptor. In animal studies it has both analgesic and anti-allodynia effects. The 9-methoxy derivative AM-1710 has similar CB2 affinity but only 54x selectivity over CB1.[1][2]

See also

References

  1. "Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity". Journal of Medicinal Chemistry 50 (26): 6493–500. December 2007. doi:10.1021/jm070441u. PMID 18038967. 
  2. "Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats". The Journal of Pharmacology and Experimental Therapeutics 327 (2): 584–91. November 2008. doi:10.1124/jpet.108.141994. PMID 18664590.