Chemistry:Bruceantin
From HandWiki
Bruceantin is a chemical compound that was first isolated from the plant Brucea antidysenterica in 1973.[1] Chemically, it is classified as a secotriterpenoid and a quassinoid.
Bucreantin has attracted interest as a potential antitumor drug because of its antineoplastic activity.[2] It inhibits the peptidyl transferase elongation reaction, resulting in decreased protein and DNA synthesis.[2] Bruceantin also has antibiotic, antiamoebic,[3] and antimalarial activity.[2]
Phase I and II clinical trials were conducted for the treatment of metastatic breast cancer and malignant melanoma, but tumor regression was not observed and clinical development was terminated.[4][5]
References
- ↑ Kupchan, S. Morris; Britton, Ronald W.; Ziegler, Myra F.; Sigel, Carl W. (1973). "Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica". J. Org. Chem. 38 (1): 178–179. doi:10.1021/jo00941a049. PMID 4682660.
- ↑ 2.0 2.1 2.2 "Bruceantin". NCI Cancer Dictionary. National Institutes of Health. https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1025.
- ↑ Gillin, F. D.; Reiner, D. S.; Suffness, M. (2021). "Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica". Antimicrobial Agents and Chemotherapy 22 (2): 342–345. doi:10.1128/AAC.22.2.342. PMID 6100431.
- ↑ Cuendet, Muriel; Pezzuto, John M. (2004). "Antitumor activity of bruceantin: an old drug with new promise". J Nat Prod 67 (2): 269–272. doi:10.1021/np030304+. PMID 14987068. Bibcode: 2004JNAtP..67..269C.
- ↑ "Bruceantin". https://drugs.ncats.io/drug/S3NW88DI4T.
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