Chemistry:Conopharyngine
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Methyl (1S,15S,17S,18S)-17-ethyl-6,7-dimethoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
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3D model (JSmol)
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| Properties | |
| C23H34N2O4 | |
| Molar mass | 402.535 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
Conopharyngine is the major alkaloid present in the leaves and stem-bark of Tabernaemontana pachysiphon and Conopharyngia durissima.[1][2][3] It is closely related voacangine and coronaridine. Conopharyngine pseudoindoxyl, a derivative of it, is also found in the same plant Tabernaemontana pachysiphon.[4]
Pharmacology
It possess central nervous system stimulant activity and produces bradycardia and hypotension in cats. It has weak acetylcholinesterase inhibitory activity and significantly increases hexobarbitone induced sleeping time.[5]
Toxicity
It has low intravenous toxicity in mice (LD50 = 143 mg/kg).[5]
See also
References
- ↑ "Tabernaemontana pachysiphon". https://uses.plantnet-project.org/en/Tabernaemontana_pachysiphon_(PROTA).
- ↑ "Phytochemical investigation of Tabernaemontana crassa". Journal of Ethnopharmacology 14 (2–3): 315–8. 1985. doi:10.1016/0378-8741(85)90096-0. PMID 4094474.
- ↑ Renner, U.; Prins, D. A.; Stoll, W. G. (1959). "Alkaloide ausConopharyngia durissima STAPF Isovoacangin, Conopharyngin, Conodurin und Conoduramin". Helvetica Chimica Acta 42 (5): 1572–1581. doi:10.1002/hlca.19590420519. ISSN 0018-019X.
- ↑ "Conopharyngine pseudoindoxyl, a new alkaloid from Tabernamontana pachysiphon Stapf. var cumminsii (Stapf.) H. Huber". The Journal of Pharmacy and Pharmacology 25 (10): 820–3. October 1973. doi:10.1111/j.2042-7158.1973.tb09948.x. PMID 4149744.
- ↑ 5.0 5.1 "Studies on the pharmacology of conopharyngine, an indole alkaloid of the voacanga series". British Journal of Pharmacology and Chemotherapy 30 (1): 173–85. May 1967. doi:10.1111/j.1476-5381.1967.tb02123.x. PMID 6039971.
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