Chemistry:FGI-104

FGI-104
Legal status
Legal status	US: Investigational New Drug ;
Identifiers
	IUPAC name 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)-6-[4-(hydroxymethyl)-3-methoxyphenyl]phenol;
PubChem CID	44158960;
ChemSpider	65322076;
Chemical and physical data
Formula	C28H30ClN3O3
Molar mass	492.008 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c4cnc1cc(Cl)ccc1c4Nc(cc2CN(CC)CC)cc(c2O)-c(cc3OC)ccc3CO;
	InChI InChI=1S/C28H30ClN3O3/c1-4-32(5-2)16-20-12-22(31-25-10-11-30-26-14-21(29)8-9-23(25)26)15-24(28(20)34)18-6-7-19(17-33)27(13-18)35-3/h6-15,33-34H,4-5,16-17H2,1-3H3,(H,30,31); Key:OFXBJOIYAJBMNY-UHFFFAOYSA-N;

Short description: Chemical compound

FGI-104 is the name of an experimental broad-spectrum antiviral drug, with activity against a range of viruses including hepatitis B, hepatitis C, HIV, Ebola virus, and Venezuelan equine encephalitis virus. ^[1]

Mechanism

The drug acts by inhibiting the protein TSG101, which transports newly manufactured virions to the exterior of an infected cell, thus breaking the replication cycle of the virus. In pre-clinical studies, FGI-104 has been shown to protect mice from Ebola virus disease.^[2]^[3]

References

↑ "FGI-104: a broad-spectrum small molecule inhibitor of viral infection". American Journal of Translational Research 1 (1): 87–98. January 2009. doi:10.1016/j.antiviral.2009.02.082. PMID 19966942.
↑ "Development of Small-Molecule Antivirals for Ebola". Medicinal Research Reviews 35 (6): 1175–94. November 2015. doi:10.1002/med.21355. PMID 26172225.
↑ "Clinical Management of Ebola Virus Disease: Current and Future Approaches". Communicable Diseases of the Developing World. Topics in Medicinal Chemistry. 29. Cham: Springer. 2015. pp. 1–36. doi:10.1007/7355_2015_5003. ISBN 978-3-319-78252-2.

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Original source: https://en.wikipedia.org/wiki/FGI-104. Read more

[KinchYunus2009-1] "FGI-104: a broad-spectrum small molecule inhibitor of viral infection". American Journal of Translational Research 1 (1): 87–98. January 2009. doi:10.1016/j.antiviral.2009.02.082. PMID 19966942.

[Janeba2015-2] "Development of Small-Molecule Antivirals for Ebola". Medicinal Research Reviews 35 (6): 1175–94. November 2015. doi:10.1002/med.21355. PMID 26172225.

[3] "Clinical Management of Ebola Virus Disease: Current and Future Approaches". Communicable Diseases of the Developing World. Topics in Medicinal Chemistry. 29. Cham: Springer. 2015. pp. 1–36. doi:10.1007/7355_2015_5003. ISBN 978-3-319-78252-2.

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Legal status	US: Investigational New Drug
Identifiers
IUPAC name 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)-6-[4-(hydroxymethyl)-3-methoxyphenyl]phenol
PubChem CID	44158960
ChemSpider	65322076
Chemical and physical data
Formula	C₂₈H₃₀ClN₃O₃
Molar mass	492.008 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c4cnc1cc(Cl)ccc1c4Nc(cc2CN(CC)CC)cc(c2O)-c(cc3OC)ccc3CO
InChI InChI=1S/C28H30ClN3O3/c1-4-32(5-2)16-20-12-22(31-25-10-11-30-26-14-21(29)8-9-23(25)26)15-24(28(20)34)18-6-7-19(17-33)27(13-18)35-3/h6-15,33-34H,4-5,16-17H2,1-3H3,(H,30,31) Key:OFXBJOIYAJBMNY-UHFFFAOYSA-N

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