Chemistry:Farglitazar

Farglitazar
Clinical data
Pregnancy; category	N/A;
ATC code	none;
Legal status
Legal status	Development discontinued;
Identifiers
	IUPAC name N-(o-Benzoylphenyl)-O-[2-(5-methyl- 2-phenyl-4-oxazolyl)ethyl]-L-tyrosine;
CAS Number	196808-45-4 ;
PubChem CID	170364;
IUPHAR/BPS	2672;
ChemSpider	148961 ;
UNII	3433GY7132;
KEGG	D04132;
ChEMBL	ChEMBL107367 ;
Chemical and physical data
Formula	C34H30N2O5
Molar mass	546.623 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccccc1)c2ccccc2N[C@H](C(=O)O)Cc5ccc(OCCc3nc(oc3C)c4ccccc4)cc5;
	InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1 ; Key:ZZCHHVUQYRMYLW-HKBQPEDESA-N ;
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Short description: Chemical compound

Farglitazar is a peroxisome proliferator-activated receptor agonist which was formerly under development by GlaxoSmithKline, but has never been marketed. It progressed to phase II clinical trials for the treatment of hepatic fibrosis, but failed to show efficacy.^[1] After reaching phase III for type 2 diabetes, further development was discontinued.^[2]^[3]

References

↑ "Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection". Gastroenterology 138 (4): 1365–73, 1373.e1-2. April 2010. doi:10.1053/j.gastro.2009.12.003. PMID 20004661.
↑ "Farglitazar". Adis Insight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800008802.
↑ "Farglitazar". pharmacodia.com. https://www.pharmacodia.com/yaodu/html/v1/chemicals/ba48bccfc0d72c73228d80154ec7bf39.html.

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Clinical data

Pregnancy category	N/A
ATC code	none
Legal status
Legal status	Development discontinued
Identifiers
IUPAC name N-(o-Benzoylphenyl)-O-[2-(5-methyl- 2-phenyl-4-oxazolyl)ethyl]-L-tyrosine
CAS Number	196808-45-4^Y
PubChem CID	170364
IUPHAR/BPS	2672
ChemSpider	148961^Y
UNII	3433GY7132
KEGG	D04132
ChEMBL	ChEMBL107367^Y
Chemical and physical data
Formula	C₃₄H₃₀N₂O₅
Molar mass	546.623 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(c1ccccc1)c2ccccc2N[C@H](C(=O)O)Cc5ccc(OCCc3nc(oc3C)c4ccccc4)cc5
InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1^N Key:ZZCHHVUQYRMYLW-HKBQPEDESA-N^N
^NY (what is this?) (verify)