Chemistry:Technetium (99mTc) medronic acid

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Short description: Chemical compound


Technetium (99mTc) medronic acid
Tc-99m medronic acid skeletal.svg
Clinical data
Trade namesMdp-Bracco
License data
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administration
Intravenous
ATC code
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Legal status
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UNII
KEGG
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Chemical and physical data
FormulaCH6O6P2 • x99mTc
Molar mass unknown
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Technetium (99mTc) medronic acid is a pharmaceutical product used in nuclear medicine to localize bone metastases[1] as well as other diseases that can alter the natural turn-over in the bone by bone scintigraphy.[2]

Chemistry

The drug is a complex of medronic acid (MDP, methylene diphosphonate), the simplest bisphosphonate, with technetium-99m (99mTc), a radionuclide that emits gamma rays. The exact structure of the complex is not known.[2][3]

Manufacture

99mTc-MDP must be prepared in a radiopharmacy. It is usually supplied as a "cold kit" to which radioactive 99mTc from a generator is added. Kit composition may vary between suppliers, but contents typically includes medronic acid, stannous chloride dihydrate and sometimes ascorbic acid.[4] Pertechnetate, eluted from the generator is added to the kit vial, which is swirled and left to stand. The labelling efficiency, an indication of how much 99mTc remains in pertechnetate form rather than bound to the MDP, can be measured using chromatography.[5][6][7][8]

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