Organization:Lieber Institute for Brain Development Research
The Lieber Institute for Brain Development (LIBD) is a nonprofit research center located in Baltimore, Maryland, that studies brain development issues such as schizophrenia.[1]
Description
The Lieber Institute was started in 2010 by Steve and Connie Lieber along with Milton and Tamar Maltz—both families have children with schizophrenia.[2][3][4] Psychiatrist Daniel R. Weinberger is the CEO.[5] Having gathered over 2,000 brains for research purposes, the institute has the largest collection of post-mortem brains diagnosed with post-traumatic stress disorder.[6] These brains are used to study the biological basis for mental illnesses.[7] In one study of post-mortem brains, LIBD researchers found that patients with schizophrenia had high levels of DNA methylation in brain regions associated with risk for schizophrenia.[8] They are also developing a drug to prevent post-traumatic stress disorder.[9]
A recent paper by Lieber scientists found that altering brain proteins caused the cells of autistic brains to behave normally.[10] The specific type of autism is called Pitt–Hopkins syndrome and researchers are now looking into possible treatments that could be used for the condition and for other types of autism.[11][12]
References
- ↑ Johns Hopkins [New Brain Research Institute Chooses Home In Johns Hopkins Bioscience Park http://www.hopkinsmedicine.org/news/media/releases/New_Brain_Research_Institute_Chooses_Home_In_Johns_Hopkins_Bioscience_Park] June 7, 2010.
- ↑ "Inside View: The Lieber Institute for Brain Development". Nature Jobs. 2016. doi:10.1038/nj0496.
- ↑ Brain and Behavior Research Foundation [Constance E. Lieber Receives 2017 Honorary Pardes Humanitarian Prize in Mental Health for Extraordinary Advocacy and Support of Psychiatric Research https://www.bbrfoundation.org/News/philanthropist-celebrated-bringing-mental-illness-out-shadows] 13 September 2017.
- ↑ Scott Dance [Lieber Institute expanding at Johns Hopkins research park http://www.baltimoresun.com/health/maryland-health/bs-bz-lieber-institute-expanding-20130720-story.html] The Baltimore Sun, 20 July 2013.
- ↑ Abbott, Alison (2011). "A radical approach to mental illness". Nature 477 (7363): 146. doi:10.1038/477146a. PMID 21900988. Bibcode: 2011Natur.477..146A.
- ↑ Emily Mullin [Inside the World’s Largest Collection of PTSD Brains https://www.technologyreview.com/s/602644/inside-the-worlds-largest-collection-of-ptsd-brains/] MIT Technology Review, October 14, 2016.
- ↑ Kathryn May [Business and the brain: How some scientists hope to cure mental illness http://business.financialpost.com/brain-health/business-and-the-brain-how-some-scientists-hope-to-cure-mental-illness] Financial Post, January 12, 2015.
- ↑ Megan Brooks [Schizophrenia Tied to Epigenetic Changes Before Birth http://www.medscape.com/viewarticle/855475] MedScape, December 4, 2015.
- ↑ Heather Walker [New drug could prevent PTSD in trauma victims http://woodtv.com/2017/02/21/new-drug-could-prevent-ptsd-in-trauma-victims/] WoodTV Channel 8, February 21, 2017.
- ↑ Rannals, Matthew D; Hamersky, Gregory R; Page, Stephanie Cerceo; Campbell, Morganne N; Briley, Aaron; Gallo, Ryan A; Phan, Badoi N; Hyde, Thomas M et al. (2016). "Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1". Neuron 90 (1): 43–55. doi:10.1016/j.neuron.2016.02.021. PMID 26971948.
- ↑ Meredith Cohn [Lieber scientists discover how rare form of autism works and a possible treatment http://www.baltimoresun.com/health/blog/bs-hs-autism-treatment-20160310-story.html] The Baltimore Sun, 11 March 2016.
- ↑ Pitt-Hopkins Research Foundation [Study Identifies Potential Treatment for Autism Spectrum Disorder https://pitthopkins.org/2016/03/10/maher-lab-identifies-potential-drug-targets-for-pitt-hopkins/] 10 March 2016.
External links
- Lieber Institute for Brain Development
- Lieber Institute studies on PubMed [1]
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