Biology:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase

From HandWiki
Short description: InterPro Family
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
Identifiers
EC number1.2.1.60
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.60) is an enzyme that catalyzes the chemical reaction

5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+

The 3 substrates of this enzyme are 5-carboxymethyl-2-hydroxymuconate semialdehyde, H2O, and NAD+, whereas its 3 products are 5-carboxymethyl-2-hydroxymuconate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme is also called carboxymethylhydroxymuconic semialdehyde dehydrogenase. This enzyme participates in tyrosine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2D4E.

References