Biology:CRTC1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.[1][2][3][4] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands[5] and various regions of the adult central nervous system.[6]

Clinical significance

Production of CRTC1 is blocked in Alzheimer's disease.[7]

See also

References

  1. "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics 33 (2): 208–13. Feb 2003. doi:10.1038/ng1083. PMID 12539049. https://zenodo.org/record/1233401. 
  2. "TORCs: transducers of regulated CREB activity". Molecular Cell 12 (2): 413–23. Aug 2003. doi:10.1016/j.molcel.2003.08.013. PMID 14536081. 
  3. "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12147–52. Oct 2003. doi:10.1073/pnas.1932773100. PMID 14506290. 
  4. "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23373. 
  5. Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers. http://atlasgeneticsoncology.org/Genes/CRTC1ID471ch19p13.html. 
  6. "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America 104 (11): 4700–5. Mar 2007. doi:10.1073/pnas.0607524104. PMID 17360587. Bibcode2007PNAS..104.4700K. 
  7. "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience 34 (17): 5776–87. Apr 2014. doi:10.1523/JNEUROSCI.5288-13.2014. PMID 24760838. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.