Biology:SARS coronavirus main proteinase

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SARS coronavirus main proteinase
3iwm.jpg
SARS main proteinase oktamer
Identifiers
EC number3.4.22.69
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

SARS coronavirus main proteinase (EC 3.4.22.69, 3cLpro, 3C-like protease, coronavirus 3C-like protease, Mpro, SARS 3C-like protease, SARS coronavirus 3CL protease, SARS coronavirus main peptidase, SARS coronavirus main protease, SARS-CoV 3CLpro enzyme, SARS-CoV main protease, SARS-CoV Mpro, severe acute respiratory syndrome coronavirus main protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

TSAVLQ-SGFRK-NH2 and SGVTFQ-!GKFKK are the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase

This cysteine protease is important in SARS coronavirus replicase polyprotein processing.

References

  1. "Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus". Biochemistry 46 (30): 8744–52. July 2007. doi:10.1021/bi0621415. PMID 17605471. 
  2. "Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase". The Journal of Biological Chemistry 279 (3): 1637–42. January 2004. doi:10.1074/jbc.m310875200. PMID 14561748. 
  3. "Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant". Bioorganic & Medicinal Chemistry 16 (21): 9400–8. November 2008. doi:10.1016/j.bmc.2008.09.057. PMID 18845442. 

External links