Biology:Amorpha-4,11-diene 12-monooxygenase
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Short description: Class of enzymes
| Amorpha-4,11-diene 12-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.14.114 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Amorpha-4,11-diene 12-monooxygenase (EC 1.14.14.114, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating).[1] This enzyme catalyses the following overall chemical reaction
- REDIRECT Template:Chemical reaction
The reaction proceeds in three oxidations, each catalysed by the enzyme, which is a cytochrome P450 protein containing heme, isolated from Artemisia annua. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate.[1][2] The product is used by the plant in the biosynthesis of artemisinin.[3]
References
- ↑ 1.0 1.1 "Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin". FEBS Letters 580 (5): 1411–6. February 2006. doi:10.1016/j.febslet.2006.01.065. PMID 16458889. Bibcode: 2006FEBSL.580.1411T.
- ↑ Enzyme 1.14.14.114 at KEGG Pathway Database.
- ↑ "From Plant to Yeast-Advances in Biosynthesis of Artemisinin". Molecules 27 (20): 6888. October 2022. doi:10.3390/molecules27206888. PMID 36296479.
External links
- Amorpha-4,11-diene+12-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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