Biology:Decaprenylphospho-beta-D-ribofuranose 2-oxidase
From HandWiki
| Decaprenylphospho-beta-D-ribofuranose 2-oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.98.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Decaprenylphospho-beta-D-ribofuranose 2-oxidase (EC 1.1.98.3, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, Rv3790, DprE1) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2
This enzyme from the bacterium Mycobacterium smegmatis participates in epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose.
Macozinone and quabodepistat are two investigational drugs that target DprE1.[3]
References
- ↑ "Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis". PLOS ONE 6 (11). 2011. doi:10.1371/journal.pone.0026675. PMID 22069462. Bibcode: 2011PLoSO...626675D.
- ↑ "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1". Journal of the American Chemical Society 134 (2): 912–915. January 2012. doi:10.1021/ja211042r. PMID 22188377.
- ↑ "Preclinical and Clinical Efficacy of Promising DprE1 Inhibitors: A Critical Review". ChemistrySelect 11 (1). January 2026. doi:10.1002/slct.202505382.
External links
- Decaprenylphospho-beta-D-ribofuranose+2-oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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