View source for Biology:1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
| EC_number  = 1.3.1.68
| CAS_number =
| GO_code    = 0018521
| image      = 
| width      = 
| caption    =  
}}
In [[Biology:Enzymology|enzymology]], a '''1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase''' ({{EC number|1.3.1.68}}) is an [[Biology:Enzyme|enzyme]] that [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD{{sup|+}} <math>\rightleftharpoons</math> 3-methylcatechol + NADH + CO{{sub|2}}

Thus, the two [[Biology:Substrate (biochemistry)|substrates]] of this enzyme are 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate and [[Chemistry:Nicotinamide adenine dinucleotide|NAD{{sup|+}}]], whereas its 3 [[Chemistry:Product|products]] are 3-methylcatechol, [[Chemistry:Nicotinamide adenine dinucleotide|NADH]], and [[Chemistry:Carbon dioxide|CO{{sub|2}}]].

This enzyme belongs to the family of [[Biology:Oxidoreductase|oxidoreductase]]s, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor.  The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)'''. This enzyme participates in toluene and xylene degradation.

==References==
{{reflist|1}}
* {{cite journal |vauthors=Higson FK, Focht DD | date = 1992 | title = Degradation of 2-methylbenzoic acid by Pseudomonas cepacia MB2 | journal = Appl. Environ. Microbiol.  | volume = 58 | pages = 194&ndash;200  | pmid = 1371658 | issue = 1 | pmc = 195191 }}

{{CH-CH oxidoreductases}}
{{Enzymes}}

[[Category:EC 1.3.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]



{{Sourceattribution|1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase}}