View source for Biology:1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase

{{Short description|Class of enzymes}}
{{Infobox enzyme
| Name       = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
| EC_number  = 5.3.1.16
| CAS_number = 37318-43-7
| GO_code    =
| image      = 4wd0.jpg
| width      = 320
| caption    = HisAp hexamer, Arthrobacter aurescens 
}}
'''1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase''' ({{EnzExplorer|5.3.1.16}}, ''N-(5-phospho-D-ribosylformimino)-5-amino-1-(5-phosphoribosyl)-4-imidazolecarboxamide isomerase'', ''phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase'', ''N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase'', ''1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide aldose-ketose-isomerase''.<ref>{{cite journal | vauthors = Margolies MN, Goldberger RF | title = Isolation of the fourth (isomerase) of histidine biosynthesis from Salmonella typhimurium | journal = The Journal of Biological Chemistry | volume = 241 | issue = 14 | pages = 3262–9 | date = July 1966 | pmid = 5330429 }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide <math>\rightleftharpoons</math> 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide

== References ==
{{reflist}}

== External links ==
* {{MeshName|1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide+isomerase}}

{{Intramolecular oxidoreductases}}
{{Enzymes}}

[[Category:EC 5.3.1]]

{{Sourceattribution|1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase}}