View source for Biology:2-dehydro-3-deoxyglucarate aldolase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = 2-dehydro-3-deoxyglucarate aldolase
| EC_number  = 4.1.2.20
| CAS_number = 37290-56-5
| GO_code    = 0008672
| image      = 4tv6.jpg
| width      = 270
| caption    = 2-dehydro-3-deoxyglucarate aldolase hexamer, Staphylococcus aureus
}}
The [[Biology:Enzyme|enzyme]] '''2-dehydro-3-deoxyglucarate aldolase''' ({{EnzExplorer|4.1.2.20}}) [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:2-dehydro-3-deoxy-<small>D</small>-glucarate <math>\rightleftharpoons</math> pyruvate + tartronate semialdehyde

This enzyme belongs to the family of [[Biology:Lyase|lyase]]s, specifically the aldehyde-lyases, which cleave carbon-carbon bonds.  The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)'''. Other names in common use include '''2-keto-3-deoxyglucarate aldolase''', '''alpha-keto-beta-deoxy-D-glucarate aldolase''', and '''2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase'''.  This enzyme participates in ascorbate and aldarate metabolism.

==Structural studies==

As of late 2007, 6 [[Biology:Tertiary structure|structures]] have been solved for this class of enzymes, with [[Biology:Protein Data Bank|PDB]] accession codes {{PDB link|1DXE}}, {{PDB link|1DXF}}, {{PDB link|1W37}}, {{PDB link|1W3I}}, {{PDB link|1W3N}}, and {{PDB link|1W3T}}.

==References==
{{Reflist|1}}
* {{cite book | vauthors = Fish DC, Blumenthal HJ | date = 1966 | chapter = 2-Keto-3-deoxy-D-glucarate aldolase | volume = 9 | pages = 529&ndash;534 | doi = 10.1016/0076-6879(66)09105-5 | title=Carbohydrate Metabolism| series = Methods in Enzymology | isbn = 978-0-12-181809-8 }}

{{Carbon-carbon lyases}}
{{Enzymes}}

[[Category:EC 4.1.2]]
[[Category:Enzymes of known structure]]



{{Sourceattribution|2-dehydro-3-deoxyglucarate aldolase}}