View source for Biology:4-phosphopantoate—beta-alanine ligase

{{Short description|Class of enzymes}}
{{Infobox enzyme
| Name       = 4-Phosphopantoate—β-alanine ligase
| EC_number  = 6.3.2.36
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''4-Phosphopantoate—β-alanine ligase''' ({{EnzExplorer|6.3.2.36}}, ''phosphopantothenate synthetase'', ''TK1686 protein'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''(R)-4-phosphopantoate:beta-alanine ligase (AMP-forming)''.<ref>{{cite journal | vauthors = Yokooji Y, Tomita H, Atomi H, Imanaka T | title = Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea | journal = The Journal of Biological Chemistry | volume = 284 | issue = 41 | pages = 28137–45 | date = October 2009 | pmid = 19666462 | pmc = 2788864 | doi = 10.1074/jbc.m109.009696 | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: ATP + (''R'')-4-phosphopantoate + β-alanine <math>\rightleftharpoons</math> AMP + diphosphate + (''R'')-4'-phosphopantothenate

The conversion of (''R'')-pantoate to (''R'')-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine.

== References ==
{{reflist}}

== External links ==
* {{MeshName|4-phosphopantoate—beta-alanine+ligase}}

{{Ligases CO CS and CN}}
{{Enzymes}}

{{DEFAULTSORT:4-phosphopantoate-beta-alanine ligase}}
[[Category:EC 6.3.2]]

{{Sourceattribution|4-phosphopantoate—beta-alanine ligase}}