View source for Biology:Blood

{{short description|Organic fluid which transports nutrients throughout the organism}}
{{Infobox anatomy
|Name = Blood
|Image = Venous and arterial blood.jpg
|Caption = Venous (darker) and arterial (brighter) blood
}}

'''Blood''' is a [[Biology:Body fluid|body fluid]] in the [[Biology:Circulatory system|circulatory system]] of [[Humans|humans]] and other [[Biology:Vertebrate|vertebrate]]s that delivers necessary substances such as [[Earth:Nutrient|nutrient]]s and [[Chemistry:Oxygen|oxygen]] to the [[Biology:Cell|cells]], and transports [[Biology:Metabolic waste|metabolic waste products]] away from those same cells.<ref>{{cite web |title=Definition of BLOOD |url=http://www.merriam-webster.com/dictionary/blood |url-status=live |archive-url=https://web.archive.org/web/20170323030751/https://www.merriam-webster.com/dictionary/blood |archive-date=23 March 2017 |access-date=4 March 2017 |website=Merriam-Webster}}</ref> Blood in the circulatory system is also known as ''peripheral blood'', and the [[Biology:Blood cell|blood cell]]s it carries, ''peripheral blood cells''.<ref name="cancer">{{cite web |title=def/peripheral-blood |url=https://www.cancer.gov/publications/dictionaries/cancer-terms/def/peripheral-blood |website=www.cancer.gov |access-date=13 September 2022 |language=en |date=2 February 2011 |archive-date=13 September 2022 |archive-url=https://web.archive.org/web/20220913202857/https://www.cancer.gov/publications/dictionaries/cancer-terms/def/peripheral-blood |url-status=live }}</ref>

Blood is composed of blood cells suspended in [[Biology:Blood plasma|blood plasma]]. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume),<ref>
{{cite web |url=http://www.fi.edu/learn/heart/blood/blood.html |title=Blood – The Human Heart |access-date=19 March 2009 |author=The Franklin Institute Inc. |url-status=dead |archive-url=https://web.archive.org/web/20090305043654/http://www.fi.edu/learn/heart/blood/blood.html |archive-date=5 March 2009}}</ref> and contains [[Biology:Protein|protein]]s, [[Chemistry:Glucose|glucose]], mineral [[Physics:Ion|ion]]s, [[Biology:Hormone|hormone]]s, [[Chemistry:Carbon dioxide|carbon dioxide]] (plasma being the main medium for excretory product transportation), and blood cells themselves. [[Biology:Albumin|Albumin]] is the main protein in plasma, and it functions to regulate the [[Physics:Colloid|colloid]]al [[Biology:Osmotic pressure|osmotic pressure]] of blood. The blood cells are mainly [[Biology:Red blood cell|red blood cell]]s (also called RBCs or erythrocytes), [[Biology:White blood cell|white blood cell]]s (also called WBCs or leukocytes), and in mammals [[Biology:Platelet|platelet]]s (also called thrombocytes).<ref>{{Cite web |date=2011-02-02 |title=Definition of red blood cell |url=https://www.cancer.gov/publications/dictionaries/cancer-terms/def/red-blood-cell |access-date=2022-04-28 |website=National Cancer Institute |language=en |archive-date=25 April 2022 |archive-url=https://web.archive.org/web/20220425130740/https://www.cancer.gov/publications/dictionaries/cancer-terms/def/red-blood-cell |url-status=live }}</ref> The most abundant cells in vertebrate blood are red blood cells.<ref>{{Cite web |last=Aryal |first=Sagar |date=2017-01-03 |title=Blood cells and its types with functions |url=https://microbiologyinfo.com/blood-cells-types-functions/ |access-date=2022-04-28 |website=Microbiology Info.com |language=en-US |archive-date=12 April 2022 |archive-url=https://web.archive.org/web/20220412041337/https://microbiologyinfo.com/blood-cells-types-functions/ |url-status=live }}</ref> These contain [[Biology:Hemoglobin|hemoglobin]], an iron-containing protein, which facilitates oxygen transport by reversibly binding to this respiratory gas thereby increasing its solubility in blood.<ref>{{Cite web |title=Low Hemoglobin: Causes & Symptoms |url=https://my.clevelandclinic.org/health/symptoms/17705-low-hemoglobin |access-date=2022-04-28 |website=Cleveland Clinic |archive-date=28 April 2022 |archive-url=https://web.archive.org/web/20220428204042/https://my.clevelandclinic.org/health/symptoms/17705-low-hemoglobin |url-status=live }}</ref> In contrast, carbon dioxide is mostly transported [[Biology:Extracellular|extracellular]]ly as [[Chemistry:Bicarbonate|bicarbonate]] ion transported in plasma.

Vertebrate blood is bright red when its hemoglobin is oxygenated and dark red when it is deoxygenated.<ref>{{Cite web |last=Séguin |first=Chantal |date=2022-01-08 |title=Did You Know That Not All Blood is Red? • The Blood Project |url=https://www.thebloodproject.com/did-you-know-13/ |access-date=2022-07-02 |website=The Blood Project |archive-date=2 July 2022 |archive-url=https://web.archive.org/web/20220702161612/https://www.thebloodproject.com/did-you-know-13/ |url-status=live }}</ref><ref>{{Cite web |date=2018-04-10 |title=Is blood blue? 7 facts about blood |url=https://www.medicalnewstoday.com/articles/321442 |access-date=2023-03-29 |website=www.medicalnewstoday.com |language=en |archive-date=29 March 2023 |archive-url=https://web.archive.org/web/20230329062539/https://www.medicalnewstoday.com/articles/321442 |url-status=live }}</ref>

Some animals, such as [[Biology:Crustacean|crustacean]]s and mollusks, use [[Biology:Hemocyanin|hemocyanin]] to carry oxygen, instead of hemoglobin.<ref>{{Cite journal |last1=Kato |first1=Sanae |last2=Matsui |first2=Takashi |last3=Gatsogiannis |first3=Christos |last4=Tanaka |first4=Yoshikazu |date=April 2018 |title=Molluscan hemocyanin: structure, evolution, and physiology |journal=Biophysical Reviews |volume=10 |issue=2 |pages=191–202 |doi=10.1007/s12551-017-0349-4 |issn=1867-2450 |pmc=5899709 |pmid=29235083}}</ref> Insects and some mollusks use a fluid called [[Biology:Hemolymph|hemolymph]] instead of blood, the difference being that hemolymph is not contained in a closed circulatory system. In most insects, this "blood" does not contain oxygen-carrying molecules such as hemoglobin because their bodies are small enough for their tracheal system to suffice for supplying oxygen.

[[Biology:Gnathostomata|Jawed vertebrates]] have an [[Biology:Adaptive immune system|adaptive immune system]], based largely on white blood cells. White blood cells help to resist infections and parasites. Platelets are important in the clotting of blood. [[Biology:Arthropod|Arthropod]]s, using hemolymph, have hemocytes as part of their [[Biology:Immune system|immune system]].

Blood is circulated around the body through [[Biology:Blood vessel|blood vessel]]s by the pumping action of the [[Biology:Heart|heart]]. In animals with [[Medicine:Lung|lung]]s, [[Biology:Artery|arterial]] blood carries oxygen from inhaled air to the tissues of the body, and [[Medicine:Vein|venous]] blood carries carbon dioxide, a waste product of [[Biology:Metabolism|metabolism]] produced by cells, from the tissues to the lungs to be exhaled.

Medical terms related to blood often begin with ''hemo-'', ''hemato-'', ''haemo-'' or ''haemato-'' from the Greek word {{lang|grc|αἷμα}} (''{{Lang|grc-latn|haima}}'') for "blood". In terms of [[Biology:Anatomy|anatomy]] and [[Biology:Histology|histology]], blood is considered a specialized form of connective tissue,<ref name="Krause2005">{{Cite book |last=Krause |first=William J. |url=https://books.google.com/books?id=cRayoldYrcUC&pg=PA67 |title=Krause's Essential Human Histology for Medical Students |publisher=Universal-Publishers |year=2005 |isbn=978-1-58112-468-2 |edition=3rd |pages=67 |language=en |access-date=21 June 2022 |archive-date=26 April 2023 |archive-url=https://web.archive.org/web/20230426075102/https://books.google.com/books?id=cRayoldYrcUC&pg=PA67 |url-status=live }}</ref> given its origin in the bones and the presence of potential molecular fibers in the form of [[Biology:Fibrinogen|fibrinogen]].{{Citation needed|date=June 2022}}

==Functions==
 [[File:1GZX Haemoglobin.png|right|thumb|Hemoglobin, a globular protein<br />green = haem (or heme) groups<br />red & blue = protein subunits]]
Blood performs many important functions within the body, including:
* Supply of [[Chemistry:Oxygen|oxygen]] to tissues (bound to [[Biology:Hemoglobin|hemoglobin]], which is carried in red cells)
* Supply of nutrients such as [[Chemistry:Glucose|glucose]], [[Chemistry:Amino acid|amino acid]]s, and [[Chemistry:Fatty acid|fatty acid]]s (dissolved in the blood or bound to [[Biology:Blood proteins|plasma proteins]] (e.g., blood lipids))
* Removal of waste such as [[Chemistry:Carbon dioxide|carbon dioxide]], [[Chemistry:Urea|urea]], and [[Chemistry:Lactic acid|lactic acid]]
* Immunological functions, including circulation of [[Biology:White blood cell|white blood cell]]s, and detection of foreign material by [[Biology:Antibody|antibodies]]
* Coagulation, the response to a broken blood vessel, the conversion of blood from a liquid to a semisolid gel to stop bleeding
* Messenger functions, including the transport of [[Biology:Hormone|hormone]]s and the signaling of [[Biology:Tissue|tissue]] damage
* Regulation of core body temperature
* [[Physics:Hydraulics|Hydraulic]] functions

==Constituents==
===In mammals===

Blood accounts for 7% of the human body weight,<ref name="alberts_table">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK26919/table/A4143/ |title=Table 22-1 Blood Cells |access-date=1 November 2012 |publisher=NCBI Bookshelf |year=2012 | last = Alberts | first = Bruce | name-list-style = vanc |website=Molecular Biology of the Cell |url-status=live |archive-url=https://web.archive.org/web/20180327160412/https://www.ncbi.nlm.nih.gov/books/NBK26919/table/A4143/ |archive-date=27 March 2018 }}</ref><ref name="PhysFactVol">{{Cite web |url=http://hypertextbook.com/facts/1998/LanNaLee.shtml |title=Volume of Blood in a Human |access-date=2012-11-01 |archive-url=https://web.archive.org/web/20121103090043/http://hypertextbook.com/facts/1998/LanNaLee.shtml |archive-date=3 November 2012 |year=2012 | last = Elert | first = Glenn | name-list-style = vanc |website=The Physics Factbook |url-status=dead}}</ref> with an average density around 1060&nbsp;kg/m<sup>3</sup>, very close to pure water's density of 1000&nbsp;kg/m<sup>3</sup>.<ref>{{cite web |url=http://hypertextbook.com/facts/2004/MichaelShmukler.shtml |title=Density of Blood |access-date=4 October 2006 |year=2004 |website=The Physics Factbook |last=Shmukler |first=Michael |url-status=dead |archive-url=https://web.archive.org/web/20060919051122/http://hypertextbook.com/facts/2004/MichaelShmukler.shtml |archive-date=19 September 2006 }}</ref> The average adult has a [[Medicine:Blood volume|blood volume]] of roughly {{convert|5|L|USpt|lk=in}} or 1.3 gallons,<ref name="PhysFactVol"/> which is composed of plasma and ''formed elements''. The formed elements are the two types of blood cell or ''corpuscle'' – the [[Biology:Red blood cell|red blood cell]]s, (erythrocytes) and [[Biology:White blood cell|white blood cell]]s (leukocytes), and the cell fragments called [[Biology:Platelet|platelet]]s<ref name="SEER">{{cite web |title=Composition of the Blood {{!}} SEER Training |url=https://training.seer.cancer.gov/leukemia/anatomy/composition.html |website=training.seer.cancer.gov |access-date=30 December 2020 |archive-date=16 October 2020 |archive-url=https://web.archive.org/web/20201016211542/https://www.training.seer.cancer.gov/leukemia/anatomy/composition.html |url-status=live }}</ref> that are involved in clotting. By volume, the red blood cells constitute about 45% of whole blood, the plasma about 54.3%, and white cells about 0.7%.

Whole blood (plasma and cells) exhibits [[Physics:Non-Newtonian fluid|non-Newtonian]] [[Medicine:Blood viscosity|fluid dynamics]].{{specify|reason="Non-Newtonian" encompasses several different types of properties.|date=April 2021}}

<gallery>
File:Krew Frakcjonowana.jpg|Human blood fractioned by centrifugation: Plasma (upper, yellow layer), buffy coat (middle, thin white layer) and erythrocyte layer (bottom, red layer) can be seen.
File:Blutkreislauf.png|Blood circulation: Red = oxygenated, blue = deoxygenated
File:Blausen 0425 Formed Elements.png|Illustration depicting formed elements of blood
File:Blut-EDTA.jpg|Two tubes of [[Chemistry:EDTA|EDTA]]-anticoagulated blood.<br /> Left tube: after standing, the RBCs have settled at the bottom of the tube.<br /> Right tube: Freshly drawn blood
</gallery>

====Cells====
{{Further|Medicine:Complete blood count}}

[[Image:Red White Blood cells.jpg|thumb|right|A [[Physics:Scanning electron microscope|scanning electron microscope]] (SEM) image of a normal red blood cell (left), a platelet (middle), and a white blood cell (right)]]
One microliter of blood contains:
* '''4.7 to 6.1&nbsp;million (male), 4.2 to 5.4&nbsp;million (female) erythrocytes:'''<ref>{{cite web |url=https://www.nlm.nih.gov/medlineplus/ency/article/003644.htm#Normal%20Values |title=Medical Encyclopedia: RBC count |website=Medline Plus |access-date=18 November 2007 |url-status=live |archive-url=https://web.archive.org/web/20071021042354/http://www.nlm.nih.gov/medlineplus/ency/article/003644.htm#Normal%20Values |archive-date=21 October 2007 }}</ref> Red blood cells contain the blood's [[Biology:Hemoglobin|hemoglobin]] and distribute oxygen. Mature red blood cells lack a [[Biology:Cell nucleus|nucleus]] and [[Biology:Organelle|organelle]]s in mammals. The red blood cells (together with endothelial vessel cells and other cells) are also marked by [[Chemistry:Glycoprotein|glycoprotein]]s that define the different [[Medicine:Human blood group systems|blood types]]. The proportion of blood occupied by red blood cells is referred to as the [[Medicine:Hematocrit|hematocrit]], and is normally about 45%. The combined surface area of all red blood cells of the human body would be roughly 2,000 times as great as the body's exterior surface.<ref>{{cite book | first1 = Robert B. | last1 = Tallitsch | first2 = Martini | last2 = Frederic | first3 = Timmons | last3 = Michael J. | name-list-style = vanc |title=Human anatomy |publisher=Pearson/Benjamin Cummings |location=San Francisco |year=2006 |page=529 |isbn=978-0-8053-7211-3 |edition= 5th}}</ref>
* '''4,000–11,000 leukocytes:'''<ref name = "Ganong WF">{{cite book | last = Ganong | first = William F. | name-list-style = vanc |title=Review of medical physiology | url = https://archive.org/details/reviewmedicalphy00gano | url-access = limited |publisher=Lange Medical Books/McGraw-Hill |location=New York |year=2003 |page=[https://archive.org/details/reviewmedicalphy00gano/page/n517 518] |isbn=978-0-07-121765-1 |edition= 21}}</ref> White blood cells are part of the body's [[Biology:Immune system|immune system]]; they destroy and remove old or aberrant cells and cellular debris, as well as attack infectious agents ([[Biology:Pathogen|pathogen]]s) and foreign substances. The cancer of leukocytes is called [[Medicine:Leukemia|leukemia]].
* '''200,000–500,000 thrombocytes:'''<ref name = "Ganong WF"/> Also called [[Biology:Platelet|platelet]]s, they take part in blood clotting (coagulation). Fibrin from the coagulation cascade creates a mesh over the [[Medicine:Platelet plug|platelet plug]].

{| class="wikitable" style="float:right; margin-left:15px"
|+ Constitution of normal blood
|-
!Parameter
!Value
!Refs.
|-
| [[Medicine:Hematocrit|Hematocrit]] ||
45 ± 7 (38–52%) for males<br />
42 ± 5 (37–47%) for females
|
|-
| [[Chemistry:PH|pH]] || 7.35–7.45
|<ref name=":1">{{Cite book |url=https://www.worldcat.org/oclc/1018308697 |title=Medical-surgical nursing : concepts for interprofessional collaborative care |date=2018 |publisher=[[Company:Elsevier|Elsevier]] |editor-first1=Donna D. |editor-last1=Ignatavicius |editor-first2=M. Linda |editor-last2=Workman |editor-first3=Cherie R. |editor-last3=Rebar |editor-first4=Nicole M. |editor-last4=Heimgartner |isbn=978-0-323-46158-0 |edition=9th |location=St. Louis, Missouri |page=190 |language=en-US |oclc=1018308697}}</ref>
|-
| [[Chemistry:Base excess|base excess]] || −3 to +3
|
|-
| P[[Chemistry:Oxygen|O<sub>2</sub>]] || 10–13 kPa (80–100&nbsp;mm Hg)
|
|-
| P[[Chemistry:Carbon dioxide|CO<sub>2</sub>]] || 4.8–5.8 kPa (35–45&nbsp;mm Hg)
|
|-
| [[Chemistry:Carbonic acid|HCO<sub>3</sub><sup>−</sup>]] || 21–27 mM
|
|-
| [[Biology:Oxygen saturation|Oxygen saturation]] ||
Oxygenated: 98–99%<br />
Deoxygenated: 75%
|
|}

====Plasma====
{{Main|Biology:Blood plasma}}
About 55% of blood is [[Biology:Blood plasma|blood plasma]], a fluid that is the blood's liquid medium, which by itself is straw-yellow in color. The blood plasma volume totals of 2.7–3.0 liters (2.8–3.2 quarts) in an average human. It is essentially an [[Chemistry:Water|aqueous]] solution containing 92% water, 8% blood plasma [[Biology:Protein|protein]]s, and trace amounts of other materials. Plasma circulates dissolved nutrients, such as [[Chemistry:Glucose|glucose]], [[Chemistry:Amino acid|amino acid]]s, and [[Chemistry:Fatty acid|fatty acid]]s (dissolved in the blood or bound to plasma proteins), and removes waste products, such as [[Chemistry:Carbon dioxide|carbon dioxide]], [[Chemistry:Urea|urea]], and [[Chemistry:Lactic acid|lactic acid]].

Other important [[Biology:List of human blood components|components]] include:
* [[Biology:Serum albumin|Serum albumin]]
* Blood-clotting factors (to facilitate coagulation)
* Immunoglobulins ([[Biology:Antibody|antibodies]])
* [[Biology:Lipoprotein|lipoprotein]] particles
* Various other [[Biology:Protein|protein]]s
* Various [[Physics:Electrolyte|electrolyte]]s (mainly [[Biology:Sodium in biology|sodium]] and [[Chemistry:Chloride|chloride]])

The term '''serum''' refers to plasma from which the clotting proteins have been removed. Most of the proteins remaining are albumin and [[Biology:Antibody|immunoglobulins]].

====Acidity====

[[Chemistry:PH#Living systems|Blood pH]] is regulated to stay within the narrow range of 7.35 to 7.45, making it slightly [[Chemistry:Base|basic]] (compensation).<ref name="Waugh">{{cite book |last1=Waugh |first1=Anne |chapter-url=https://archive.org/details/rosswilsonanatom0000waug_x2u4/page/22/mode/2up |title=Anatomy and Physiology in Health and Illness |last2=Grant |first2=Allison |publisher=Churchill Livingstone Elsevier |year=2007 |isbn=978-0-443-10102-1 |edition=Tenth |page=22 |chapter=2 |chapter-url-access=registration |name-list-style=vanc}}</ref><ref name="ReferenceA">{{MerckManual|12|157|a||Acid–Base Regulation and Disorders}}</ref> Extra-cellular fluid in blood that has a pH below 7.35 is too [[Chemistry:Acid|acid]]ic, whereas blood pH above 7.45 is too basic.<ref name=":1" /> A pH below 6.9 or above 7.8 is usually lethal.<ref name=":1" /> Blood pH, [[Chemistry:Oxygen#partial pressure|partial pressure of oxygen (pO<sub>2</sub>)]], [[Chemistry:PCO2|partial pressure of carbon dioxide (pCO<sub>2</sub>)]], and [[Chemistry:Bicarbonate|bicarbonate]] (HCO<sub>3</sub><sup>−</sup>) are carefully regulated by a number of [[Homeostasis|homeostatic mechanisms]], which exert their influence principally through the respiratory system and the urinary system to control the [[Chemistry:Acid–base homeostasis|acid–base balance]] and respiration, which is called compensation.<ref name=":1" /> An [[Medicine:Arterial blood gas test|arterial blood gas test]] measures these. Plasma also circulates [[Biology:Hormone|hormone]]s transmitting their messages to various tissues. The list of normal [[Medicine:Reference ranges for blood tests|reference ranges]] for various blood electrolytes is extensive.

===In non-mammalian vertebrates===
[[File:Newbloodm.jpg|thumbnail|Vertebrate red blood cell types, measurements in micrometers]]
[[Image:Frogrbc1000x.jpg|thumb|Frog red blood cells magnified 1000 times|left]]
[[Image:Turtlerbc1000x.jpg|thumb|right|Turtle red blood cells magnified 1000 times]]
[[Image:Chickenrbc1000x.jpg|thumb|right|Chicken red blood cells magnified 1000 times]]
[[Image:Humanrbc1000x.jpg|thumb|Human red blood cells magnified 1000 times]]

Human blood is typical of that of mammals, although the precise details concerning cell numbers, size, [[Biology:Protein structure|protein structure]], and so on, vary somewhat between species. In non-mammalian vertebrates, however, there are some key differences:<ref name="VB">{{cite book |last1=Romer |first1=Alfred Sherwood |url=https://archive.org/details/vertebratebody0000rome_a5a9/page/404/mode/2up |title=The Vertebrate Body |last2=Parsons |first2=Thomas S. |publisher=Holt-Saunders International |year=1977 |isbn=978-0-03-910284-5 |location=Philadelphia |pages=404–406 |url-access=registration |name-list-style=vanc}}</ref>
* Red blood cells of non-mammalian vertebrates are flattened and ovoid in form, and retain their cell nuclei.
* There is considerable variation in the types and proportions of white blood cells; for example, acidophils are generally more common than in humans.
* Platelets are unique to mammals; in other vertebrates, small nucleated, spindle cells called thrombocytes are responsible for blood clotting instead.

==Physiology==
===Circulatory system===
[[File:Diagram of the human heart (cropped).svg|thumb|Circulation of blood through the human heart]]

{{main|Biology:Circulatory system}}
Blood is circulated around the body through [[Biology:Blood vessel|blood vessel]]s by the pumping action of the [[Biology:Heart|heart]]. In humans, blood is pumped from the strong left ventricle of the heart through [[Biology:Artery|arteries]] to peripheral [[Biology:Tissue|tissues]] and returns to the right atrium of the heart through [[Medicine:Vein|vein]]s. It then enters the right [[Medicine:Ventricle (heart)|ventricle]] and is pumped through the pulmonary artery to the [[Medicine:Lung|lung]]s and returns to the left atrium through the pulmonary veins. Blood then enters the left ventricle to be circulated again. Arterial blood carries oxygen from inhaled air to all of the cells of the body, and venous blood carries carbon dioxide, a waste product of [[Biology:Metabolism|metabolism]] by [[Biology:Cell|cells]], to the lungs to be exhaled. However, one exception includes pulmonary arteries, which contain the most deoxygenated blood in the body, while the pulmonary veins contain oxygenated blood.

Additional return flow may be generated by the movement of [[Biology:Skeletal muscle|skeletal muscle]]s, which can compress veins and push blood through the valves in veins toward the right atrium.

The blood circulation was famously described by William Harvey in 1628.<ref>{{cite web |title=Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus |url=http://www.rarebookroom.org/Control/hvyexc/index.html |first=William |last=Harvey | name-list-style = vanc |language=la |year=1628 |url-status=live |archive-url=https://web.archive.org/web/20101127002138/http://rarebookroom.org/Control/hvyexc/index.html |archive-date=27 November 2010 }}</ref>

===Cell production and degradation===
In vertebrates, the various cells of blood are made in the [[Biology:Bone marrow|bone marrow]] in a process called hematopoiesis, which includes erythropoiesis, the production of red blood cells; and [[Biology:Myelopoiesis|myelopoiesis]], the production of white blood cells and platelets. During childhood, almost every human bone produces red blood cells; as adults, red blood cell production is limited to the larger bones: the bodies of the vertebrae, the breastbone (sternum), the ribcage, the pelvic bones, and the bones of the upper arms and legs. In addition, during childhood, the [[Biology:Thymus|thymus]] gland, found in the mediastinum, is an important source of T lymphocytes.<ref>{{cite book |last1=Williams |first1=Peter W. |url=https://archive.org/details/graysanatomy0000gray_m7a1 |title=Gray's anatomy |last2=Gray |first2=Henry David |publisher=C. Livingstone |year=1989 |isbn=978-0-443-02588-4 |edition=37th |location=New York |url-access=registration |name-list-style=vanc}}</ref>
The proteinaceous component of blood (including clotting proteins) is produced predominantly by the [[Biology:Liver|liver]], while hormones are produced by the endocrine glands and the watery fraction is regulated by the [[Biology:Hypothalamus|hypothalamus]] and maintained by the kidney.

Healthy erythrocytes have a plasma life of about 120 days before they are degraded by the [[Biology:Spleen|spleen]], and the [[Biology:Kupffer cell|Kupffer cell]]s in the liver. The liver also clears some proteins, lipids, and amino acids. The kidney actively secretes waste products into the [[Biology:Urine|urine]].

==={{anchor|Oxygen transport}}Oxygen transport===
{{Further|Medicine:Oxygen saturation}}
[[File:Oxyhaemoglobin dissociation curve.png|thumb|Basic hemoglobin saturation curve. It is moved to the right in higher acidity (more dissolved carbon dioxide) and to the left in lower acidity (less dissolved carbon dioxide)|left]]
About 98.5%<ref>{{Cite book|title=Fundamentals of anatomy & physiology|last=Frederic|first=Martini|date=2009|publisher=Pearson/Benjamin Cummings|others=Nath, Judi Lindsley|isbn=978-0321539106|edition= 8th |location=San Francisco|pages=657|oclc=173683666}}</ref> of the [[Chemistry:Oxygen|oxygen]] in a sample of arterial blood in a healthy human breathing air at sea-level pressure is chemically combined with the [[Biology:Hemoglobin|hemoglobin]]. About 1.5% is physically dissolved in the other blood liquids and not connected to hemoglobin. The hemoglobin molecule is the primary transporter of oxygen in [[Biology:Mammal|mammal]]s and many other species (for exceptions, see below). Hemoglobin has an oxygen binding capacity between 1.36 and 1.40 ml O<sub>2</sub> per gram hemoglobin,<ref>{{cite journal | vauthors = Dominguez de Villota ED, Ruiz Carmona MT, Rubio JJ, de Andrés S | s2cid = 10029560 | title = Equality of the in vivo and in vitro oxygen-binding capacity of haemoglobin in patients with severe respiratory disease | journal = British Journal of Anaesthesia | volume = 53 | issue = 12 | pages = 1325–8 | date = December 1981 | pmid = 7317251 | doi = 10.1093/bja/53.12.1325 | doi-access = free }}</ref> which increases the total blood oxygen capacity seventyfold,<ref name=brsphys>{{cite book |last=Costanzo |first=Linda S. |name-list-style=vanc |title=Physiology |publisher=Lippincott Williams & Wilkins |location=Hagerstown, Maryland |year=2007 |isbn=978-0-7817-7311-9 |url-access=registration |url=https://archive.org/details/physiology00cost_0 }}</ref> compared to if oxygen solely were carried by its solubility of 0.03&nbsp;ml O<sub>2</sub> per liter blood per mm&nbsp;Hg partial pressure of oxygen (about 100&nbsp;mm&nbsp;Hg in arteries).<ref name=brsphys/>

With the exception of pulmonary and umbilical arteries and their corresponding veins, arteries carry '''oxygenated blood''' away from the heart and deliver it to the body via [[Biology:Arteriole|arteriole]]s and [[Biology:Capillary|capillaries]], where the oxygen is consumed; afterwards, venules and veins carry '''deoxygenated blood''' back to the heart.

Under normal conditions in adult humans at rest, hemoglobin in blood leaving the lungs is about 98–99% [[Medicine:Oxygen saturation|saturated with oxygen]], achieving an oxygen delivery between 950 and 1150 ml/min<ref name=edwards>[http://www.edwards.com/SiteCollectionImages/edwards/products/presep/ar04313hemodynpocketcard.pdf Edwards Lifesciences LLC – Normal Hemodynamic Parameters – Adult] {{webarchive|url=https://web.archive.org/web/20101110081655/http://www.edwards.com/SiteCollectionImages/edwards/products/presep/ar04313hemodynpocketcard.pdf |date=10 November 2010 }} 2009</ref> to the body. In a healthy adult at rest, oxygen consumption is approximately 200–250 ml/min,<ref name=edwards/> and deoxygenated blood returning to the lungs is still roughly 75%<ref>{{cite web |url=http://home.hia.no/~stephens/ventphys.htm|archive-url=https://web.archive.org/web/20100323054138/http://home.hia.no/~stephens/ventphys.htm|url-status=dead|archive-date=23 March 2010 |title=Ventilatory Physiology and Endurance |date=23 March 2010 |access-date=4 March 2017}}</ref><ref>[https://web.archive.org/web/20040224085741/http://groups.msn.com/TransplantSupportLungHeartLungHeart/oxygen2.msnw Transplant Support- Lung, Heart/Lung, Heart] MSN groups</ref> (70 to 78%)<ref name=edwards/> saturated. Increased oxygen consumption during sustained exercise reduces the oxygen saturation of venous blood, which can reach less than 15% in a trained athlete; although breathing rate and blood flow increase to compensate, oxygen saturation in arterial blood can drop to 95% or less under these conditions.<ref>{{cite journal | vauthors = Mortensen SP, Dawson EA, Yoshiga CC, Dalsgaard MK, Damsgaard R, Secher NH, González-Alonso J | title = Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans | journal = The Journal of Physiology | volume = 566 | issue = Pt 1 | pages = 273–85 | date = July 2005 | pmid = 15860533 | pmc = 1464731 | doi = 10.1113/jphysiol.2005.086025 | display-authors = etal }}</ref> Oxygen saturation this low is considered dangerous in an individual at rest (for instance, during surgery under anesthesia). Sustained hypoxia (oxygenation less than 90%), is dangerous to health, and severe hypoxia (saturations less than 30%) may be rapidly fatal.<ref>{{cite web |url=http://manbit.com/PAC/chapters/P30.cfm|archive-url=https://web.archive.org/web/20100925053056/http://manbit.com/PAC/chapters/P30.cfm|url-status=dead|archive-date=25 September 2010 |title=Blood gas and Saturation measurements |date=25 September 2010 |access-date=4 March 2017}}</ref>

A [[Biology:Fetus|fetus]], receiving oxygen via the [[Biology:Placenta|placenta]], is exposed to much lower oxygen pressures (about 21% of the level found in an adult's lungs), so fetuses produce another form of hemoglobin with a much higher affinity for oxygen ([[Biology:Fetal hemoglobin|hemoglobin F]]) to function under these conditions.<ref>{{cite web |url=http://members.aol.com/Bio50/LecNotes/lecnot20.html|archive-url=https://web.archive.org/web/19990502195422/http://members.aol.com/Bio50/LecNotes/lecnot20.html|url-status=dead|archive-date=2 May 1999 |title=Lecture Notes-20 |date=2 May 1999 |access-date=4 March 2017}}</ref>

===Carbon dioxide transport===
CO<sub>2</sub> is carried in blood in three different ways. (The exact percentages vary depending whether it is arterial or venous blood). Most of it (about 70%) is converted to bicarbonate ions {{chem2|HCO3−}} by the enzyme [[Biology:Carbonic anhydrase|carbonic anhydrase]] in the red blood cells by the reaction {{chem2|CO2 + H2O -> H2CO3 -> H+ + HCO3−}}; about 7% is dissolved in the plasma; and about 23% is bound to hemoglobin as [[Chemistry:Carbamino|carbamino]] compounds.<ref>{{cite book | last = Martini | first = Frederic | name-list-style = vanc |year=2007 |title=Anatomy and Physiology |url=https://books.google.com/books?id=joJb82gVsLoC&pg=PA643 |publisher=Rex Bookstore, Inc. |page=643 |isbn=9789712348075 |display-authors=0 |url-status=live |archive-url=https://web.archive.org/web/20160501022224/https://books.google.com/books?id=joJb82gVsLoC&pg=PA643 |archive-date=1 May 2016 }}</ref><ref>''Vander's Human Physiology'' reported similar numbers: 60% carried as bicarbonate, 30% bound to hemoglobin as [[Biology:Carbaminohemoglobin|carbaminohemoglobin]], and 10% physically dissolved. {{cite book |last1=Widmaier |first1=Eric P. |url=https://archive.org/details/humanphysiologym0000widm/page/493/mode/2up |title=Vander's Human Physiology |last2=Raff |first2=Hershel |last3=Strang |first3=Kevin T. |date=2003 |publisher=McGraw-Hill Education |isbn=978-0-07-288074-8 |edition=9th |at=p. 493 (ch. Respiratory physiology § Transport of carbon dioxide in blood) |url-access=registration |name-list-style=vanc}}</ref>

Hemoglobin, the main oxygen-carrying molecule in red blood cells, carries both oxygen and carbon dioxide. However, the CO<sub>2</sub> bound to hemoglobin does not bind to the same site as oxygen. Instead, it combines with the N-terminal groups on the four globin chains. However, because of [[Biology:Allosteric regulation|allosteric]] effects on the hemoglobin molecule, the binding of CO<sub>2</sub> decreases the amount of oxygen that is bound for a given partial pressure of oxygen. The decreased binding to carbon dioxide in the blood due to increased oxygen levels is known as the [[Biology:Haldane effect|Haldane effect]], and is important in the transport of carbon dioxide from the tissues to the lungs. A rise in the partial pressure of CO<sub>2</sub> or a lower pH will cause offloading of oxygen from hemoglobin, which is known as the [[Medicine:Bohr effect|Bohr effect]].

===Transport of hydrogen ions===
Some oxyhemoglobin loses oxygen and becomes deoxyhemoglobin. Deoxyhemoglobin binds most of the hydrogen ions as it has a much greater affinity for more hydrogen than does oxyhemoglobin.

===Lymphatic system===
{{main|Biology:Lymphatic system}}
In mammals, blood is in equilibrium with [[Biology:Lymph|lymph]], which is continuously formed in tissues from blood by capillary ultrafiltration. Lymph is collected by a system of small lymphatic vessels and directed to the thoracic duct, which drains into the left subclavian vein, where lymph rejoins the systemic blood circulation.

===Thermoregulation===
Blood circulation transports heat throughout the body, and adjustments to this flow are an important part of [[Physics:Thermoregulation|thermoregulation]]. Increasing blood flow to the surface (e.g., during warm weather or strenuous exercise) causes warmer skin, resulting in faster heat loss. In contrast, when the external temperature is low, blood flow to the extremities and surface of the skin is reduced and to prevent heat loss and is circulated to the important organs of the body, preferentially.

=== Rate of flow ===
Rate of blood flow varies greatly between different organs. Liver has the most abundant blood supply with an approximate flow of 1350 ml/min. Kidney and brain are the second and the third most supplied organs, with 1100 ml/min and ~700 ml/min, respectively.<ref name=":0">{{Cite book |url=https://archive.org/details/guytonhalltextbo0000hall/page/204/mode/2up |title=Guyton and Hall Textbook of Medical Physiology |publisher=Saunders |year=2015 |isbn=978-1455770052 |page=204 |url-access=registration}}</ref>

Relative rates of blood flow per 100 g of tissue are different, with kidney, adrenal gland and thyroid being the first, second and third most supplied tissues, respectively.<ref name=":0" />

===Hydraulic functions===
The restriction of blood flow can also be used in specialized tissues to cause engorgement, resulting in an [[Medicine:Erection|erection]] of that tissue; examples are the [[Biology:Erectile tissue|erectile tissue]] in the penis and clitoris.

Another example of a hydraulic function is the [[Biology:Jumping spider|jumping spider]], in which blood forced into the legs under pressure causes them to straighten for a powerful jump, without the need for bulky muscular legs.<ref>{{cite encyclopedia |url=https://www.britannica.com/eb/topic-559817/spider |encyclopedia=Encyclopædia Britannica online |title=Spiders: circulatory system |access-date=25 November 2007 |url-status=live |archive-url=https://web.archive.org/web/20071112190558/https://www.britannica.com/eb/topic-559817/spider |archive-date=12 November 2007 }}</ref>

===Invertebrates===
In insects, the blood (more properly called [[Biology:Hemolymph|hemolymph]]) is not involved in the transport of oxygen. (Openings called [[Biology:Trachea#Invertebrates|tracheae]] allow oxygen from the air to diffuse directly to the tissues.) Insect blood moves nutrients to the tissues and removes waste products in an open system.

Other invertebrates use respiratory proteins to increase the oxygen-carrying capacity. Hemoglobin is the most common respiratory protein found in nature. [[Biology:Hemocyanin|Hemocyanin]] (blue) contains copper and is found in [[Biology:Crustacean|crustacean]]s and [[Biology:Mollusca|mollusks]]. It is thought that [[Biology:Tunicate|tunicate]]s (sea squirts) might use [[Biology:Vanabins|vanabins]] (proteins containing [[Chemistry:Vanadium|vanadium]]) for respiratory pigment (bright-green, blue, or orange).

In many invertebrates, these oxygen-carrying proteins are freely soluble in the blood; in vertebrates they are contained in specialized red blood cells, allowing for a higher concentration of respiratory pigments without increasing [[Physics:Viscosity|viscosity]] or damaging blood filtering organs like the kidneys.

Giant tube worms have unusual hemoglobins that allow them to live in extraordinary environments. These hemoglobins also carry sulfides normally fatal in other animals.

==Color==
{{Multiple image
| image1            =
| image2            =
| caption1          = Blood from a [[Medicine:Vein|vein]]
| caption2          = Blood from an [[Biology:Artery|artery]]
| alt1              = Black blood
| alt2              = Normal red blood
}}
The coloring matter of blood ('''hemochrome''') is largely due to the protein in the blood responsible for oxygen transport. Different groups of organisms use different proteins.

===Hemoglobin===
{{main|Biology:Hemoglobin}}
[[File:Bleeding finger.jpg|thumb|Capillary blood from a bleeding finger]]
Hemoglobin is the principal determinant of the color of blood in vertebrates. Each molecule has four heme groups, and their interaction with various molecules alters the exact color. In [[Biology:Vertebrate|vertebrate]]s and other hemoglobin-using creatures, arterial blood and capillary blood are bright red, as oxygen imparts a strong red color to the heme group. Deoxygenated blood is a darker shade of red; this is present in veins, and can be seen during [[Medicine:Blood donation|blood donation]] and when venous blood samples are taken. This is because the spectrum of light absorbed by hemoglobin differs between the oxygenated and deoxygenated states.<ref>{{cite web |last=Prahl |title=Optical Absorption of Hemoglobin |url=http://omlc.ogi.edu/spectra/hemoglobin/ |access-date=30 December 2012 |url-status=live |archive-url=https://web.archive.org/web/20020105184047/http://omlc.ogi.edu/spectra/hemoglobin/ |archive-date=5 January 2002 }}</ref>

Blood in [[Medicine:Carbon monoxide poisoning|carbon monoxide poisoning]] is bright red, because [[Chemistry:Carbon monoxide|carbon monoxide]] causes the formation of [[Chemistry:Carboxyhemoglobin|carboxyhemoglobin]]. In [[Chemistry:Cyanide|cyanide]] poisoning, the body cannot use oxygen, so the venous blood remains oxygenated, increasing the redness. There are some conditions affecting the heme groups present in hemoglobin that can make the skin appear blue&nbsp;– a symptom called [[Medicine:Cyanosis|cyanosis]]. If the heme is oxidized, [[Biology:Methemoglobin|methemoglobin]], which is more brownish and cannot transport oxygen, is formed. In the rare condition [[Medicine:Sulfhemoglobinemia|sulfhemoglobinemia]], arterial hemoglobin is partially oxygenated, and appears dark red with a bluish hue.

Veins close to the surface of the skin appear blue for a variety of reasons. However, the factors that contribute to this alteration of [[Philosophy:Visual perception|color perception]] are related to the light-scattering properties of the skin and the processing of visual input by the [[Biology:Visual cortex|visual cortex]], rather than the actual color of the venous blood.<ref>{{cite journal | vauthors = Kienle A, Lilge L, Vitkin IA, Patterson MS, Wilson BC, Hibst R, Steiner R | title = Why do veins appear blue? A new look at an old question | journal = Applied Optics | volume = 35 | issue = 7 | pages = 1151 | date = March 1996 | pmid = 21085227 | doi = 10.1364/AO.35.001151 | url = http://www.imt.liu.se/edu/courses/TBMT36/pdf/blue.pdf | archive-url = https://web.archive.org/web/20120210145120/https://www.imt.liu.se/edu/courses/TBMT36/pdf/blue.pdf | url-status = dead | bibcode = 1996ApOpt..35.1151K | archive-date = 10 February 2012 }}</ref>

[[Biology:Skink|Skink]]s in the genus ''[[Biology:Prasinohaema|Prasinohaema]]'' have green blood due to a buildup of the waste product [[Chemistry:Biliverdin|biliverdin]].<ref>{{cite journal | vauthors = Austin CC, Perkins SL | title = Parasites in a biodiversity hotspot: a survey of hematozoa and a molecular phylogenetic analysis of Plasmodium in New Guinea skinks | journal = The Journal of Parasitology | volume = 92 | issue = 4 | pages = 770–7 | date = August 2006 | pmid = 16995395 | doi = 10.1645/GE-693R.1 | s2cid = 1937837 | url = https://digitalcommons.lsu.edu/biosci_pubs/84 | access-date = 16 November 2021 | archive-date = 26 April 2023 | archive-url = https://web.archive.org/web/20230426075114/https://digitalcommons.lsu.edu/biosci_pubs/84/ | url-status = live }}</ref>

===Hemocyanin===
{{main|Biology:Hemocyanin}}
The blood of most mollusks – including cephalopods and gastropods – as well as some [[Biology:Arthropod|arthropod]]s, such as [[Biology:Horseshoe crab|horseshoe crab]]s, is blue, as it contains the copper-containing protein hemocyanin at concentrations of about 50&nbsp;grams per liter.<ref name = "AHC 2004 p276-7"/> Hemocyanin is colorless when deoxygenated and dark blue when oxygenated. The blood in the circulation of these creatures, which generally live in cold environments with low oxygen tensions, is grey-white to pale yellow,<ref name = "AHC 2004 p276-7">{{cite book |chapter-url=https://books.google.com/books?id=0OSAKny-6M4C |first=Carl N |last=Shuster |editor=Shuster, Carl N Jr |editor2=Barlow, Robert B |editor3=Brockmann, H. Jane |title=The American Horseshoe Crab |chapter=Chapter 11: A blue blood: the circulatory system |publisher=Harvard University Press |year=2004 |isbn=978-0-674-01159-5 |pages=276–277 |access-date=6 May 2020 |archive-date=26 April 2023 |archive-url=https://web.archive.org/web/20230426075104/https://books.google.com/books?id=0OSAKny-6M4C |url-status=live }}</ref> and it turns dark blue when exposed to the oxygen in the air, as seen when they bleed.<ref name = "AHC 2004 p276-7"/> This is due to change in color of hemocyanin when it is oxidized.<ref name = "AHC 2004 p276-7"/> Hemocyanin carries oxygen in [[Biology:Extracellular fluid|extracellular fluid]], which is in contrast to the intracellular oxygen transport in mammals by hemoglobin in RBCs.<ref name = "AHC 2004 p276-7"/>

===Chlorocruorin===
{{main|Biology:Chlorocruorin}}
The blood of most [[Biology:Annelid|annelid]] worms and some marine polychaetes use chlorocruorin to transport oxygen. It is green in color in dilute solutions.<ref name=ScienceAnswer>Carnegie Library of Pittsburgh, ''The Handy Science Answer Book'', p. 465, Visible Ink Press, 2011 {{ISBN|1578593212}}.</ref>

===Hemerythrin===
{{main|Biology:Hemerythrin}}
Hemerythrin is used for oxygen transport in the marine invertebrates sipunculids, priapulids, [[Biology:Brachiopod|brachiopod]]s, and the annelid worm, magelona. Hemerythrin is violet-pink when oxygenated.<ref name=ScienceAnswer/>

===Hemovanadin===
{{main|Biology:Hemovanadin}}
The blood of some species of [[Earth:Ascidiacea|ascidians]] and tunicates, also known as sea squirts, contains proteins called vanadins. These proteins are based on [[Chemistry:Vanadium|vanadium]], and give the creatures a concentration of vanadium in their bodies 100 times higher than the surrounding seawater. Unlike hemocyanin and hemoglobin, hemovanadin is not an oxygen carrier. When exposed to oxygen, however, vanadins turn a mustard yellow.

==Disorders==
===General medical ===
* Disorders of volume
** Injury can cause blood loss through bleeding.<ref>{{cite web |url=http://www.fi.edu/learn/heart/blood/blood.html |title=Blood – The Human heart |publisher=The Franklin Institute |access-date=19 March 2009 |url-status=dead |archive-url=https://web.archive.org/web/20090305043654/http://www.fi.edu/learn/heart/blood/blood.html |archive-date=5 March 2009}}</ref> A healthy adult can lose almost 20% of blood volume (1&nbsp;L) before the first symptom, restlessness, begins, and 40% of volume (2&nbsp;L) before [[Medicine:Shock (circulatory)|shock]] sets in. Thrombocytes are important for blood coagulation and the formation of blood clots, which can stop bleeding. Trauma to the internal organs or bones can cause [[Medicine:Internal bleeding|internal bleeding]], which can sometimes be severe.
** [[Medicine:Dehydration|Dehydration]] can reduce the blood volume by reducing the water content of the blood. This would rarely result in [[Medicine:Shock (circulatory)|shock]] (apart from the very severe cases) but may result in [[Medicine:Orthostatic hypotension|orthostatic hypotension]] and fainting.
* Disorders of circulation
** Shock is the ineffective [[Medicine:Perfusion|perfusion]] of tissues, and can be caused by a variety of conditions including blood loss, infection, poor [[Medicine:Cardiac output|cardiac output]].
** [[Medicine:Atherosclerosis|Atherosclerosis]] reduces the flow of blood through arteries, because atheroma lines arteries and narrows them. Atheroma tends to increase with age, and its progression can be compounded by many causes including smoking, [[Medicine:Hypertension|high blood pressure]], excess circulating lipids (hyperlipidemia), and [[Medicine:Diabetes|diabetes]] mellitus.
** Coagulation can form a [[Medicine:Thrombosis|thrombosis]], which can obstruct vessels.
** Problems with blood composition, the pumping action of the heart, or narrowing of blood vessels can have many consequences including hypoxia (lack of oxygen) of the tissues supplied. The term ''ischemia'' refers to tissue that is inadequately perfused with blood, and ''infarction'' refers to tissue death ([[Biology:Necrosis|necrosis]]), which can occur when the blood supply has been blocked (or is very inadequate).

===Hematological ===
* Anemia
** Insufficient red cell mass ([[Medicine:Anemia|anemia]]) can be the result of bleeding, blood disorders like [[Medicine:Thalassemia|thalassemia]], or nutritional deficiencies, and may require one or more [[Medicine:Blood transfusion|blood transfusion]]s. Anemia can also be due to a [[Medicine:Genetic disorder|genetic disorder]] in which the red blood cells do not function effectively. Anemia can be confirmed by a [[Medicine:Blood test|blood test]] if the hemoglobin value is less than 13.5&nbsp;gm/dl in men or less than 12.0&nbsp;gm/dl in women.<ref>{{cite web |url=http://www.hematology.org/Patients/Anemia/ |title=The Role of Red Blood Cells in Anemia |access-date=2017-05-22 |url-status=dead |archive-url=https://web.archive.org/web/20170518202410/http://www.hematology.org/Patients/Anemia/ |archive-date=18 May 2017 }}</ref> Several countries have [[Medicine:Blood bank|blood bank]]s to fill the demand for transfusable blood. A person receiving a blood transfusion must have a [[Biology:Blood type|blood type]] compatible with that of the donor.
** Sickle-cell anemia
* Disorders of cell proliferation
** [[Medicine:Leukemia|Leukemia]] is a group of cancers of the blood-forming tissues and cells.
** Non-cancerous overproduction of red cells ([[Medicine:Polycythemia vera|polycythemia vera]]) or platelets (essential thrombocytosis) may be premalignant.
** [[Medicine:Myelodysplastic syndrome|Myelodysplastic syndrome]]s involve ineffective production of one or more cell lines.
* Disorders of coagulation
** Hemophilia is a [[Medicine:Genetic disorder|genetic illness]] that causes dysfunction in one of the blood's clotting mechanisms. This can allow otherwise inconsequential wounds to be life-threatening, but more commonly results in [[Medicine:Hemarthrosis|hemarthrosis]], or bleeding into joint spaces, which can be crippling.
** Ineffective or insufficient platelets can also result in [[Medicine:Coagulopathy|coagulopathy]] (bleeding disorders).
** Hypercoagulable state (thrombophilia) results from defects in regulation of platelet or clotting factor function, and can cause thrombosis.
* Infectious disorders of blood
** Blood is an important vector of infection. HIV, the virus that causes AIDS, is transmitted through contact with blood, semen or other body secretions of an infected person. [[Medicine:Hepatitis B|Hepatitis B]] and [[Medicine:Hepatitis C|C]] are transmitted primarily through blood contact. Owing to blood-borne infections, bloodstained objects are treated as a biohazard.
** Bacterial infection of the blood is [[Medicine:Bacteremia|bacteremia]] or [[Medicine:Sepsis|sepsis]]. Viral Infection is viremia. [[Medicine:Malaria|Malaria]] and [[Medicine:Trypanosomiasis|trypanosomiasis]] are blood-borne parasitic infections.

===Carbon monoxide poisoning===
{{main|Medicine:Carbon monoxide poisoning}}
Substances other than oxygen can bind to hemoglobin; in some cases, this can cause irreversible damage to the body. Carbon monoxide, for example, is extremely dangerous when carried to the blood via the lungs by inhalation, because carbon monoxide irreversibly binds to hemoglobin to form carboxyhemoglobin, so that less hemoglobin is free to bind oxygen, and fewer oxygen molecules can be transported throughout the blood. This can cause suffocation insidiously. A fire burning in an enclosed room with poor ventilation presents a very dangerous hazard, since it can create a build-up of carbon monoxide in the air. Some carbon monoxide binds to hemoglobin when smoking tobacco.<ref>{{cite journal | vauthors = Blumenthal I | title = Carbon monoxide poisoning | journal = Journal of the Royal Society of Medicine | volume = 94 | issue = 6 | pages = 270–2 | date = June 2001 | pmid = 11387414 | pmc = 1281520 | doi = 10.1177/014107680109400604 }}</ref>

==Treatments==
===Transfusion===
{{further|Medicine:Blood transfusion}}
[[File:Bloodbags.jpg|thumb|Venous blood collected during blood donation]]
Blood for transfusion is obtained from human donors by blood donation and stored in a [[Medicine:Blood bank|blood bank]]. There are many different [[Biology:Blood type|blood type]]s in humans, the [[Biology:ABO blood group system|ABO blood group system]], and the Rhesus blood group system being the most important. Transfusion of blood of an incompatible blood group may cause severe, often fatal, complications, so crossmatching is done to ensure that a compatible blood product is transfused.

Other blood products administered intravenously are platelets, blood plasma, cryoprecipitate, and specific coagulation factor concentrates.

===Intravenous administration===
Many forms of medication (from [[Chemistry:Antibiotic|antibiotic]]s to [[Medicine:Chemotherapy|chemotherapy]]) are administered intravenously, as they are not readily or adequately absorbed by the digestive tract.

After severe acute blood loss, liquid preparations, generically known as plasma expanders, can be given intravenously, either solutions of salts (NaCl, KCl, CaCl<sub>2</sub> etc.) at physiological concentrations, or colloidal solutions, such as dextrans, [[Biology:Human serum albumin|human serum albumin]], or fresh frozen plasma. In these emergency situations, a plasma expander is a more effective life-saving procedure than a blood transfusion, because the metabolism of transfused red blood cells does not restart immediately after a transfusion.

===Letting===
{{main|Unsolved:Bloodletting}}
In modern [[Medicine:Evidence-based medicine|evidence-based medicine]], bloodletting is used in management of a few rare diseases, including hemochromatosis and polycythemia. However, [[Unsolved:Bloodletting|bloodletting]] and leeching were common unvalidated interventions used until the 19th century, as many diseases were incorrectly thought to be due to an excess of blood, according to [[Biography:Hippocrates|Hippocratic]] medicine.

==Etymology==
[[Image:Jan Janský, 1902.jpg|thumb|upright|Jan Janský is credited with the first classification of blood into four types (A, B, AB, and O)]]
English ''blood'' ([[Social:Old English|Old English]] ''blod'') derives from Germanic and has cognates with a similar range of meanings in all other Germanic languages (e.g. German ''Blut'', Swedish ''blod'', Gothic ''blōþ''). There is no accepted [[Social:Proto-Indo-European language|Indo-European]] etymology.<ref>{{Cite OED|blood}}</ref>

==History==
===Classical Greek medicine===
Robin Fåhræus (a Swedish physician who devised the [[Erythrocyte sedimentation rate|erythrocyte sedimentation rate]]) suggested that the Ancient Greek system of humorism, wherein the body was thought to contain four distinct bodily fluids (associated with different temperaments), were based upon the observation of blood clotting in a transparent container. When blood is drawn in a glass container and left undisturbed for about an hour, four different layers can be seen. A dark clot forms at the bottom (the "black bile"). Above the clot is a layer of red blood cells (the "blood"). Above this is a whitish layer of white blood cells (the "phlegm"). The top layer is clear yellow serum (the "yellow bile").<ref>{{cite journal | vauthors = Hart GD | title = Descriptions of blood and blood disorders before the advent of laboratory studies | journal = British Journal of Haematology | volume = 115 | issue = 4 | pages = 719–28 | date = December 2001 | pmid = 11843802 | doi = 10.1046/j.1365-2141.2001.03130.x | s2cid = 10602937 | url = http://www.bloodmed.com/home/hannpdf/bjh3130.pdf | archive-url = https://web.archive.org/web/20110708073035/http://www.bloodmed.com/home/hannpdf/bjh3130.pdf | url-status = dead | archive-date = 8 July 2011 }}</ref>{{failed verification|date=January 2015}}

===Types===
The ABO blood group system was discovered in the year 1900 by [[Biography:Karl Landsteiner|Karl Landsteiner]]. Jan Janský is credited with the first classification of blood into the four types (A, B, AB, and O) in 1907, which remains in use today. In 1907 the first [[Medicine:Blood transfusion|blood transfusion]] was performed that used the ABO system to predict compatibility.<ref>{{Cite web|url=https://www.redcrossblood.org/learn-about-blood/history-blood-transfusion|title=History of Blood Transfusion &#124; American Red Cross|website=redcrossblood.org|access-date=21 March 2021|archive-date=4 February 2016|archive-url=https://web.archive.org/web/20160204103229/http://www.redcrossblood.org/learn-about-blood/history-blood-transfusion|url-status=live}}</ref> The first non-direct transfusion was performed on 27 March 1914. The Rhesus factor was discovered in 1937.

==Culture and religion==

Due to its importance to life, blood is associated with a large number of beliefs. One of the most basic is the use of blood as a symbol for family relationships through birth/parentage; to be "related by blood" is to be related by ancestry or descendence, rather than marriage. This bears closely to bloodlines, and sayings such as "[[Social:Blood is thicker than water|blood is thicker than water]]" and "bad blood", as well as "[[Social:Blood brother|Blood brother]]".

Blood is given particular emphasis in the [[Religion:Islam|Islamic]], [[Religion:Judaism|Jewish]], and [[Religion:Christianity|Christian]] religions, because Leviticus 17:11 says "the life of a creature is in the blood." This phrase is part of the Levitical law forbidding the drinking of blood or eating meat with the blood still intact instead of being poured off.

Mythic references to blood can sometimes be connected to the life-giving nature of blood, seen in such events as childbirth, as contrasted with the blood of injury or death.

===Indigenous Australians===
In many indigenous Australian Aboriginal peoples' traditions, [[Ochre|ochre]] (particularly red) and blood, both high in iron content and considered Maban, are applied to the bodies of dancers for ritual. As Lawlor states:{{blockquote|
In many Aboriginal rituals and ceremonies, red ochre is rubbed all over the naked bodies of the dancers. In secret, sacred male ceremonies, blood extracted from the veins of the participant's arms is exchanged and rubbed on their bodies. Red ochre is used in similar ways in less-secret ceremonies. Blood is also used to fasten the feathers of birds onto people's bodies. Bird feathers contain a protein that is highly magnetically sensitive.<ref>{{cite book | last = Lawlor | first = Robert | name-list-style = vanc |title=Voices of the first day: awakening in the Aboriginal dreamtime |publisher=Inner Traditions International |location=Rochester, VT |year=1991 |pages=102–103 |isbn=978-0-89281-355-1}}</ref>}} Lawlor comments that blood employed in this fashion is held by these peoples to attune the dancers to the invisible energetic realm of the Dreamtime. Lawlor then connects these invisible energetic realms and [[Physics:Magnetic field|magnetic field]]s, because iron is [[Physics:Magnetism|magnetic]].

===European paganism===
Among the Germanic tribes, blood was used during their sacrifices; the ''[[Unsolved:Blót|Blót]]s''. The blood was considered to have the power of its originator, and, after the butchering, the blood was sprinkled on the walls, on the statues of the gods, and on the participants themselves. This act of sprinkling blood was called ''blóedsian'' in Old English, and the terminology was borrowed by the Roman Catholic Church becoming ''to bless'' and ''blessing''. The [[Social:Hittite language|Hittite]] word for blood, ''ishar'' was a cognate to words for "oath" and "bond", see [[Social:Ishara|Ishara]].
The {{wipe|Ancient Greece}} believed that the blood of the gods, ''ichor'', was a substance that was poisonous to mortals.

As a relic of Germanic Law, the [[Social:Cruentation|cruentation]], an ordeal where the corpse of the victim was supposed to start bleeding in the presence of the murderer, was used until the early 17th century.<ref>{{Cite journal |last=Brittain |first=Robert P. |date=1965 |title=Cruentation: In Legal Medicine and in Literature |journal=Medical History |language=en |volume=9 |issue=1 |pages=82–88 |doi=10.1017/S0025727300030179 |pmid=14252331 |issn=0025-7273|pmc=1033446 }}</ref>

===Christianity===
In [[Religion:Book of Genesis|Genesis]] 9:4, God prohibited Noah and his sons from eating blood (see Noahide Law). This command continued to be observed by the [[Religion:Eastern Orthodox Church|Eastern Orthodox Church]].

It is also found in the Bible that when the Angel of Death came around to the Hebrew house that the first-born child would not die if the angel saw lamb's blood wiped across the doorway.

At the [[Religion:Council of Jerusalem|Council of Jerusalem]], the [[Religion:Apostles in the New Testament|apostles]] prohibited certain Christians from consuming blood&nbsp;– this is documented in Acts 15:20 and 29. This chapter specifies a reason (especially in verses 19–21): It was to avoid offending Jews who had become Christians, because the Mosaic Law Code prohibited the practice.

Christ's blood is the means for the [[Religion:Atonement in Christianity|atonement]] of sins. Also, "... the blood of Jesus Christ his [God] Son cleanseth us from all sin." (1 John 1:7), "... Unto him [God] that loved us, and washed us from our sins in his own blood." (Revelation 1:5), and "And they overcame him (Satan) by the blood of the Lamb [Jesus the Christ], and by the word of their testimony ..." (Revelation 12:11).

Some Christian churches, including Roman Catholicism, [[Religion:Eastern Orthodox Church|Eastern Orthodoxy]], Oriental Orthodoxy, and the Assyrian Church of the East teach that, when consecrated, the [[Religion:Eucharist|Eucharist]]ic wine [[Religion:Transubstantiation|actually becomes]] the [[Religion:Blood of Christ|blood of Jesus]] for worshippers to drink. Thus in the consecrated wine, Jesus becomes spiritually and physically present. This teaching is rooted in the Last Supper, as written in the four gospels of the Bible, in which Jesus stated to his disciples that the bread that they ate was his body, and the wine was his blood. ''"This cup is the new testament in my blood, which is shed for you." ({{sourcetext|source=Bible|version=King James|book=Luke |chapter=22|verse=20}})''.

Most forms of Protestantism, especially those of a Methodist or Presbyterian lineage, teach that the wine is no more than a symbol of the blood of Christ, who is spiritually but not physically present. Lutheran theology teaches that the body and blood is [[Religion:Consubstantiation|present together "in, with, and under"]] the bread and wine of the Eucharistic feast.

===Judaism===
In [[Religion:Judaism|Judaism]], animal blood may not be consumed even in the smallest quantity (Leviticus 3:17 and elsewhere); this is reflected in Jewish dietary laws (Kashrut). Blood is purged from meat by rinsing and soaking in water (to loosen clots), salting and then rinsing with water again several times.<ref>[http://www.chabad.org/library/article_cdo/aid/82678/jewish/Koshering-Meat.htm Koshering Meat.] {{webarchive|url=https://web.archive.org/web/20131216084120/http://www.chabad.org/library/article_cdo/aid/82678/jewish/Koshering-Meat.htm |date=16 December 2013 }} Chabad.org.</ref> Eggs must also be checked and any blood spots removed before consumption.<ref>[http://www.chabad.org/library/howto/wizard_cdo/aid/113470/jewish/Removing-the-Blood.htm Removing the Blood.] {{webarchive|url=https://web.archive.org/web/20131216084034/http://www.chabad.org/library/howto/wizard_cdo/aid/113470/jewish/Removing-the-Blood.htm |date=16 December 2013 }} Chabad.org.</ref> Although blood from fish is biblically kosher, it is rabbinically forbidden to consume fish blood to avoid the appearance of breaking the Biblical prohibition.<ref>Citron, R. Aryeh. [http://www.chabad.org/library/article_cdo/aid/1182104/jewish/All-About-Kosher-Fish.htm All About Kosher Fish.] {{webarchive|url=https://web.archive.org/web/20131216084101/http://www.chabad.org/library/article_cdo/aid/1182104/jewish/All-About-Kosher-Fish.htm |date=16 December 2013 }} Chabad.org.</ref>

Another ritual involving blood involves the covering of the blood of [[Biology:Fowl|fowl]] and game after slaughtering (Leviticus 17:13); the reason given by the Torah is: "Because the life of the animal is [in] its blood" (ibid 17:14). In relation to human beings, [[Unsolved:Kabbalah|Kabbalah]] expounds on this verse that the [[Religion:Animal soul|animal soul]] of a person is in the blood, and that physical desires stem from it.

Likewise, the mystical reason for salting temple sacrifices and slaughtered meat is to remove the blood of animal-like passions from the person. By removing the animal's blood, the animal energies and life-force contained in the blood are removed, making the meat fit for human consumption.<ref>Schneerson, R. Menachem M. ''Igrot Kodesh'', vol. vii, p. 270.</ref>

===Islam===
Consumption of food containing blood is forbidden by Islamic dietary laws. This is derived from the statement in the Qur'an, sura Al-Ma'ida (5:3): "Forbidden to you (for food) are: dead meat, blood, the flesh of swine, and that on which has been invoked the name of other than Allah."

Blood is considered unclean, hence there are specific methods to obtain physical and ritual status of cleanliness once bleeding has occurred. Specific rules and prohibitions apply to [[Medicine:Menstruation|menstruation]], postnatal bleeding and irregular vaginal bleeding. When an animal has been slaughtered, the animal's neck is cut in a way to ensure that the spine is not severed, hence the brain may send commands to the heart to pump blood to it for oxygen. In this way, blood is removed from the body, and the meat is generally now safe to cook and eat. In modern times, blood transfusions are generally not considered against the rules.

===Jehovah's Witnesses===
{{main|Unsolved:Jehovah's Witnesses and blood transfusions}}

Based on their interpretation of scriptures such as Acts 15:28, 29 ("Keep abstaining...from blood."), many Jehovah's Witnesses neither consume blood nor accept transfusions of whole blood or its major components: red blood cells, white blood cells, platelets (thrombocytes), and plasma. Members may personally decide whether they will accept medical procedures that involve their own blood or substances that are further fractionated from the four major components.<ref>''The Watchtower'' 15 June 2004, p. 22, "Be Guided by the Living God"</ref>

===Vampirism===
{{main|Unsolved:Vampire}}
[[Unsolved:Vampire|Vampire]]s are mythical creatures that drink blood directly for sustenance, usually with a preference for human blood. Cultures all over the world have myths of this kind; for example the '[[Biology:Nosferatu|Nosferatu]]' legend, a human who achieves damnation and immortality by drinking the blood of others, originates from Eastern European folklore. Ticks, [[Biology:Leech|leech]]es, female [[Biology:Mosquito|mosquito]]es, [[Biology:Vampire bat|vampire bat]]s, and an assortment of other natural creatures do consume the blood of other animals, but only bats are associated with vampires. This has no relation to vampire bats, which are [[Earth:New World|New World]] creatures discovered well after the origins of the European myths.

==Other uses==
===Forensic and archaeological===
Blood residue can help forensic investigators identify weapons, reconstruct a criminal action, and link suspects to the crime. Through [[Bloodstain pattern analysis|bloodstain pattern analysis]], forensic information can also be gained from the spatial distribution of bloodstains.

Blood residue analysis is also a technique used in archeology.

===Artistic===
Blood is one of the body fluids that has been used in art.<ref>[http://artscad.com/A.nsf/Opra/SRVV-6MDNX5 "Nostalgia"] Artwork in blood {{webarchive |url=https://web.archive.org/web/20090108093007/http://artscad.com/A.nsf/Opra/SRVV-6MDNX5 |date=8 January 2009 }}</ref> In particular, the performances of Viennese Actionist Hermann Nitsch, Istvan Kantor, Franko B, Lennie Lee, Ron Athey, Yang Zhichao, Lucas Abela and Kira O'Reilly, along with the photography of Andres Serrano, have incorporated blood as a prominent visual element. Marc Quinn has made sculptures using frozen blood, including a cast of his own head made using his own blood.

===Genealogical===
The term ''blood'' is used in [[Social:Genealogy|genealogical circles]] to refer to one's ancestry, [[Biology:Human evolution|origins]], and [[Social:Ethnic group|ethnic background]] as in the word ''[[Biology:Heredity|bloodline]]''. Other terms where blood is used in a family history sense are ''blue-blood'', ''royal blood'', ''mixed-blood'' and ''[[Social:Kinship terminology|blood relative]]''.

== See also ==
{{Div col|colwidth=20em}}
* [[Medicine:Autotransfusion|Autotransfusion]]
* Blood as food
* [[Physics:Blood pressure|Blood pressure]]
* Blood substitutes ("artificial blood")
* [[Medicine:Blood test|Blood test]]
* [[Medicine:Hematology|Hematology]]
* Hemophobia
* [[Chemistry:Luminol|Luminol]], a visual test for blood left at crime scenes.
* [[Chemistry:Oct-1-en-3-one|Oct-1-en-3-one]] ("Smell" of blood)
* Taboo food and drink: Blood
{{div col end}}

== References ==
{{Reflist}}

== External links ==
* [https://www.ncbi.nlm.nih.gov/books/NBK2261 Blood Groups and Red Cell Antigens.] Free online book at [[Organization:National Center for Biotechnology Information|NCBI]] Bookshelf ID: NBK2261
* [https://web.archive.org/web/20161016200738/http://histology-world.com/photoalbum/thumbnails.php?album=7 Blood Photomicrographs]

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[[Category:Hematology]]
[[Category:Tissues (biology)]]

{{Sourceattribution|Blood}}