View source for Biology:CCL6

{{Short description|Protein fragments in rodents}}
{{protein
| Name = chemokine (C-C motif) ligand 6
| caption = 
| image = 
| width = 
| HGNCid = 
| Symbol = CCL6
| AltSymbols = SCYA6, C10, MRP-1
| EntrezGene = 20305 
| OMIM = 
| RefSeq = NM_009139
| UniProt = P27784
| PDB = 
| ECnumber = 
| Chromosome = 11
| Arm = 
| Band = 
| LocusSupplementaryData = 
}}

'''Chemokine (C-C motif) ligand 6''' (CCL6) is a small [[Biology:Cytokine|cytokine]] belonging to the CC [[Biology:Chemokine|chemokine]] family that has only been identified in [[Biology:Rodent|rodent]]s.

In mice, CCL6 is expressed in cells from [[Biology:Neutrophil|neutrophil]] and [[Biology:Macrophage|macrophage]] lineages, and can be greatly induced under conditions suitable for myeloid cell differentiation. It is highly expressed in [[Biology:Bone marrow|bone marrow]] cultures that have been stimulated with the [[Biology:Cytokine|cytokine]] GM-CSF. Some low levels of gene expression also occur in certain cell lines of myeloid origin (e.g. the immature myeloid cell lines ''DA3'' and ''32D cl3'', and the [[Biology:Macrophage|macrophage]] cell line ''P388D'') that can also be greatly induced in culture with GM-CSF. However, in activated [[Biology:T cell|T cell]] lines, expression of CCL6 is greatly reduced.<ref>Orlofsky et al. Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes. Cell Regul. 2 (5), 403-412 (1991).</ref> CCL6 can also be induced in the mouse lung by the cytokine interleukin 13.<ref name = ma>Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172(3):1872-81.</ref> Mouse CCL6 is located on [[Biology:Chromosome|chromosome]] 11.<ref>Berger et al. The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines. DNA Cell Biol. 12 (9), 839-847 (1993)</ref> The cell surface receptor for CCL6 is believed to be the chemokine receptor [[Biology:Chemokine receptor#CCR1|CCR1]].<ref name = ma/>

==References==
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{{Chemokine receptor modulators}}

[[Category:Cytokines]]



{{Sourceattribution|CCL6}}