View source for Biology:DRD1IP

{{Infobox_gene}}
'''Neuron-specific vesicular protein calcyon''' is a [[Biology:Protein|protein]] that in humans is encoded by the ''CALY'' [[Biology:Gene|gene]].<ref name="pmid17623072">{{cite journal | vauthors = Heijtz RD, Alexeyenko A, Castellanos FX | title = Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD | journal = Behavioral and Brain Functions | volume = 3 | issue = 1 | pages = 33 | date = July 2007 | pmid = 17623072 | pmc = 1949817 | doi = 10.1186/1744-9081-3-33 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DRD1IP dopamine receptor D1 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50632| access-date = }}</ref> Its alternative name is '''Calcyon'''.

== Function ==

The protein encoded by this gene is a type II single [[Biology:Transmembrane protein|transmembrane protein]]. It is required for maximal stimulated [[Chemistry:Calcium|calcium]] release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with [[Biology:Dopamine receptor D1|dopamine receptor D1]] and may interact with other DA receptor subtypes and/or GPCRs.<ref name="entrez" />

== References ==
{{Reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Milligan G, White JH | title = Protein-protein interactions at G-protein-coupled receptors | journal = Trends in Pharmacological Sciences | volume = 22 | issue = 10 | pages = 513–8 | date = October 2001 | pmid = 11583808 | doi = 10.1016/S0165-6147(00)01801-0 }}
* {{cite journal | vauthors = Ali MK, Bergson C | title = Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51654–63 | date = December 2003 | pmid = 14534309 | doi = 10.1074/jbc.M305803200 | doi-access = free }}
* {{cite journal | vauthors = Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J | title = CALCYON gene variation, schizophrenia, and cocaine dependence | journal = American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics | volume = 125B | issue = 1 | pages = 25–30 | date = February 2004 | pmid = 14755439 | doi = 10.1002/ajmg.b.20092 | s2cid = 24881261 }}
* {{cite journal | vauthors = Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL | title = Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder | journal = Molecular Psychiatry | volume = 10 | issue = 12 | pages = 1117–25 | date = December 2005 | pmid = 16172615 | doi = 10.1038/sj.mp.4001737 | doi-access = free }}
* {{cite journal | vauthors = Xiao J, Dai R, Negyessy L, Bergson C | title = Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 22 | pages = 15182–93 | date = June 2006 | pmid = 16595675 | doi = 10.1074/jbc.M600265200 | doi-access = free }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 }}
* {{cite journal | vauthors = Kruusmägi M, Zelenin S, Brismar H, Scott L | title = Intracellular dynamics of calcyon, a neuron-specific vesicular protein | journal = NeuroReport | volume = 18 | issue = 15 | pages = 1547–51 | date = October 2007 | pmid = 17885599 | doi = 10.1097/WNR.0b013e3282f03f51 | s2cid = 24544827 }}
{{refend}}



{{Sourceattribution|DRD1IP|1}}