View source for Biology:Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

{{Infobox enzyme
| Name = Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
| EC_number = 2.4.1.260
| CAS_number = 
| IUBMB_EC_number = 2/4/1/260
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase''' ({{EC number|2.4.1.260}}, ''[[Biology:ALG12|ALG12]]'', ''ALG12 mannosyltransferase'', ''ALG12 alpha1,6mannosyltransferase'', ''dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase'', ''dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase'', ''EBS4'', ''Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,6-mannosyltransferase''.<ref>{{cite journal | vauthors = Frank CG, Aebi M | title = ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis | journal = Glycobiology | volume = 15 | issue = 11 | pages = 1156–63 | date = November 2005 | pmid = 15987956 | doi = 10.1093/glycob/cwj002 }}</ref><ref>{{cite journal | vauthors = Hong Z, Jin H, Fitchette AC, Xia Y, Monk AM, Faye L, Li J | title = Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis | journal = The Plant Cell | volume = 21 | issue = 12 | pages = 3792–802 | date = December 2009 | pmid = 20023196 | pmc = 2814505 | doi = 10.1105/tpc.109.070284 }}</ref><ref>{{cite journal | vauthors = Cipollo JF, Trimble RB | title = The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man- residues of Glc3Man9GlcNAc2-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus | journal = Glycobiology | volume = 12 | issue = 11 | pages = 749–62 | date = November 2002 | pmid = 12460943 | doi = 10.1093/glycob/cwf082 }}</ref><ref>{{cite journal | vauthors = Grubenmann CE, Frank CG, Kjaergaard S, Berger EG, Aebi M, Hennet T | title = ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg | journal = Human Molecular Genetics | volume = 11 | issue = 19 | pages = 2331–9 | date = September 2002 | pmid = 12217961 | doi = 10.1093/hmg/11.19.2331 }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <math>\rightleftharpoons</math> D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate

== References ==
{{reflist}}

== External links ==
* {{MeshName|Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol+alpha-1,6-mannosyltransferase}}

{{Glycosyltransferases}}
{{Enzymes}}

[[Category:EC 2.4.1]]

{{Sourceattribution|Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase|1}}