View source for Biology:Glycoside hydrolase family 70

{{Infobox protein family
| Symbol = Glyco_hydro_70
| Name = Glycosyl hydrolase family 70
| image = 
| width = 
| caption = 
| Pfam = PF02324
| Pfam_clan = CL0058 
| InterPro = IPR003318
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = GH70
| CDD = 
}}
In molecular biology, '''glycoside hydrolase family 70''' is a [[Biology:Protein family|family]] of [[Biology:Glycoside hydrolase|glycoside hydrolase]]s.

Glycoside hydrolases {{EC number|3.2.1.}} are a widespread group of enzymes that hydrolyse the [[Chemistry:Glycosidic bond|glycosidic bond]] between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.<ref name="PUB000048702">{{cite journal|vauthors=Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G|date=July 1995|title=Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=92|issue=15|pages=7090–4|doi=10.1073/pnas.92.15.7090|pmc=41477|pmid=7624375|bibcode=1995PNAS...92.7090H|doi-access=free}}</ref><ref name="PUB000052662">{{cite journal|vauthors=Davies G, Henrissat B|date=September 1995|title=Structures and mechanisms of glycosyl hydrolases|journal=Structure|volume=3|issue=9|pages=853–9|doi=10.1016/S0969-2126(01)00220-9|pmid=8535779|doi-access=free}}</ref><ref>{{cite journal|vauthors=Henrissat B, Bairoch A|date=June 1996|title=Updating the sequence-based classification of glycosyl hydrolases|journal=The Biochemical Journal|volume=316|issue=Pt 2|pages=695–6|pmc=1217404|pmid=8687420|doi=10.1042/bj3160695}}</ref> This classification is available on the [[Biology:CAZy|CAZy]] web site,<ref>{{Cite web|url=http://www.cazy.org/|title=Home|website=CAZy.org|language=en|access-date=2018-03-06}}</ref><ref>{{cite journal|vauthors=Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B|date=January 2014|title=The carbohydrate-active enzymes database (CAZy) in 2013|url= |journal=Nucleic Acids Research|volume=42|issue=Database issue|pages=D490–5|doi=10.1093/nar/gkt1178|pmid=24270786|pmc=3965031}}</ref> and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.<ref>{{Cite web|url=http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_70|title=Glycoside Hydrolase Family 70|website=CAZypedia.org|language=en|access-date=2018-03-06}}</ref><ref>{{cite journal|date=December 2018|title=Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes|journal=Glycobiology|volume=28|issue=1|pages=3–8|doi=10.1093/glycob/cwx089|pmid=29040563|author1=CAZypedia Consortium|url=https://hal.archives-ouvertes.fr/hal-01886461/file/Hehemann_2018_01.pdf|doi-access=free}}</ref>

This family includes glucosyltransferases or sucrose 6-glycosyl transferases (GTF-S) ({{EC number|2.4.1.5}}[http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_70 CAZY GH_70]) which catalyse the transfer of D-glucopyramnosyl units from [[Chemistry:Sucrose|sucrose]] onto acceptor molecules.<ref name="PUB00008098">{{cite journal |vauthors=Croux C, Monchois V, Willemot RM, Remaud-simeon M, Monsan P |title=Cloning and sequencing of a gene coding for a novel dextransucrase from Leuconostoc mesenteroides NRRL B-1299 synthesizing only alpha (1-6) and alpha (1-3) linkages |journal=Gene |volume=182 |issue=1–2 |pages=23–32 |year=1996 |pmid=8982063 |doi=10.1016/S0378-1119(96)00443-X}}</ref> Some members of this family contain a [[Biology:Cell wall|cell wall]]-binding repeat.

==References==
{{reflist}}

{{InterPro content|IPR003318}}
{{Sugar hydrolases}}
{{Enzymes}}

[[Category:EC 3.2.1]]
[[Category:Protein families]]

{{Sourceattribution|Glycoside hydrolase family 70}}