View source for Biology:Indole-3-glycerol-phosphate lyase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = Indole-3-glycerol-phosphate lyase
| EC_number  = 4.1.2.8
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}

The [[Biology:Enzyme|enzyme]] '''indole-3-glycerol-phosphate lyase''' ({{EnzExplorer|4.1.2.8}}) [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <math>\rightleftharpoons</math> indole + D-glyceraldehyde 3-phosphate

This enzyme belongs to the family of [[Biology:Lyase|lyase]]s, specifically the aldehyde-lyases, which cleave carbon-carbon bonds.  The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''(1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming)'''. Other names in common use include '''tryptophan synthase alpha''', '''TSA''', '''indoleglycerolphosphate aldolase''', '''indole glycerol phosphate hydrolase''', '''indole synthase''', '''indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase''', '''indole-3-glycerol phosphate lyase''', '''IGL''', '''BX1''', '''(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate''', and '''D-glyceraldehyde-3-phosphate-lyase'''.  This enzyme participates in [[Biology:Benzoxazinone biosynthesis|benzoxazinone biosynthesis]].

==References==
{{reflist|1}}
* {{cite journal | author = YANOFSKY C | date = 1956 | title = The enzymatic conversion of anthranilic acid to indole | journal = J. Biol. Chem.  | volume = 223 | pages = 171&ndash;84  | pmid = 13376586 | issue = 1 | doi = 10.1016/S0021-9258(18)65126-9 | doi-access = free }}
* {{cite journal |author1 = SP, Simcox K |author2 =Gierl A | date = 1997 | title = Analysis of a chemical plant defense mechanism in grasses | journal = Science  | volume = 277 | pages = 696&ndash;699 | doi = 10.1126/science.277.5326.696 | pmid=9235894 | issue=5326}}
* {{cite journal | vauthors = Frey M, Stettner C, Pare PW, Schmelz EA, Tumlinson JH, Gierl A | date = 2000 | title = An herbivore elicitor activates the gene for indole emission in maize | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 97 | pages = 14801&ndash;6  | pmid = 11106389 | doi = 10.1073/pnas.260499897 | issue = 26 | pmc = 18999 | bibcode = 2000PNAS...9714801F | doi-access = free }}
* {{cite journal | vauthors = Melanson D, Chilton MD, Masters-Moore D, Chilton WS | date = 1997 | title = A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 94 | pages = 13345&ndash;50  | pmid = 9371848 | doi = 10.1073/pnas.94.24.13345 | issue = 24 | pmc = 24311 | bibcode = 1997PNAS...9413345M | doi-access = free }}

{{Carbon-carbon lyases}}
{{Enzymes}}

[[Category:EC 4.1.2]]
[[Category:Enzymes of unknown structure]]



{{Sourceattribution|Indole-3-glycerol-phosphate lyase}}