View source for Biology:Methanosarcina-phenazine hydrogenase

{{infobox enzyme
| Name       = Methanosarcina-phenazine hydrogenase
| EC_number  = 1.12.98.3
| CAS_number = 9027-05-8
| GO_code    = 0051911
| image      =
| width      = 
| caption    =  
}}
In [[Biology:Enzymology|enzymology]], a '''Methanosarcina-phenazine hydrogenase''' ({{EC number|1.12.98.3}}) is an [[Biology:Enzyme|enzyme]] that [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:H<sub>2</sub> + 2-(2,3-dihydropentaprenyloxy)phenazine <math>\rightleftharpoons</math> 2-dihydropentaprenyloxyphenazine

Thus, the two [[Biology:Substrate (biochemistry)|substrates]] of this enzyme are [[Chemistry:Hydrogen|H<sub>2</sub>]] and 2-(2,3-dihydropentaprenyloxy)phenazine, whereas its [[Chemistry:Product|product]] is 2-dihydropentaprenyloxyphenazine.

This enzyme belongs to the family of [[Biology:Oxidoreductase|oxidoreductase]]s, specifically those acting on hydrogen as donor with other, known, acceptors.  The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase'''. Other names in common use include '''methanophenazine hydrogenase''', and '''methylviologen-reducing hydrogenase'''.

==References==
{{reflist|1}}
* {{cite journal | vauthors = Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U | date = 1998 | title = Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1 | journal = J. Bacteriol.  | volume = 180 | pages = 2027&ndash;32  | pmid = 9555882 | issue = 8 | pmc = 107126 }}
* {{cite journal | vauthors = Deppenmeier U, Lienard T, Gottschalk G | date = 1999 | title = Novel reactions involved in energy conservation by methanogenic archaea | journal = FEBS Lett.  | volume = 457 | pages = 291&ndash;7  | pmid = 10471795 | doi = 10.1016/S0014-5793(99)01026-1 | issue = 3 | doi-access = free }}
* {{cite journal | vauthors = Beifuss U, Tietze M, Baumer S, Deppenmeier U | date = 2000 | title = Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals | journal = Angew. Chem. Int. Ed. Engl.  | volume = 39 | pages = 2470&ndash;2472  | pmid = 10941105 | issue = 14 | doi = 10.1002/1521-3773(20000717)39:14<2470::AID-ANIE2470>3.0.CO;2-R }}

{{Hydrogen oxidoreductases}}
{{Enzymes}}

[[Category:EC 1.12.98]]
[[Category:Enzymes of unknown structure]]



{{Sourceattribution|Methanosarcina-phenazine hydrogenase}}